Back to Search
Start Over
Different Genetic Associations of the IgE Production among Fetus, Infancy and Childhood
Different Genetic Associations of the IgE Production among Fetus, Infancy and Childhood
- Source :
- PLoS ONE, Vol 8, Iss 8, p e70362 (2013), PLoS ONE
- Publication Year :
- 2013
- Publisher :
- Public Library of Science (PLoS), 2013.
-
Abstract
- Elevation of serum IgE levels has long been associated with allergic diseases. Many genes have been linked to IgE production, but few have been linked to the developmental aspects of genetic association with IgE production. To clarify developmental genetic association, we investigated what genes and gene-gene interactions affect IgE levels among fetus, infancy and childhood in Taiwan individuals. A birth cohort of 571 children with completion of IgE measurements from newborn to 1.5, 3, and 6 years of age was subject to genetic association analysis on the 384-customized SNPs of 159 allergy candidate genes. Fifty-three SNPs in 37 genes on innate and adaptive immunity, and stress and response were associated with IgE production. Polymorphisms of the IL13, and the HLA-DPA1 and HLA-DQA1 were, respectively, the most significantly associated with the IgE production at newborn and 6 years of age. Analyses of gene-gene interactions indentified that the combination of NPSR1, rs324981 TT with FGF1, rs2282797 CC had the highest risk (85.7%) of IgE elevation at 1.5 years of age (P=1.46 × 10(-4)). The combination of IL13, CYFIP2 and PDE2A was significantly associated with IgE elevation at 3 years of age (P=5.98 × 10(-7)), and the combination of CLEC2D, COLEC11 and CCL2 was significantly associated with IgE elevation at 6 years of age (P=6.65 × 10(-7)). Our study showed that the genetic association profiles of the IgE production among fetus, infancy and childhood are different. Genetic markers for early prediction and prevention of allergic sensitization may rely on age-based genetic association profiles.
- Subjects :
- Male
Candidate gene
Allergy
Multifactor Dimensionality Reduction
Pulmonology
Epidemiology
lcsh:Medicine
Adaptive Immunity
Developmental and Pediatric Neurology
Immunoglobulin E
Pediatrics
Cohort Studies
Allergic sensitization
Child
lcsh:Science
Multidisciplinary
Allergy and Hypersensitivity
Statistics
Innate Immunity
Child, Preschool
Medicine
Female
Research Article
Clinical Research Design
Immunology
Single-nucleotide polymorphism
Biostatistics
Biology
Polymorphism, Single Nucleotide
Fetus
Genetics
Hypersensitivity
medicine
Humans
Genetic Association Studies
Genetic association
lcsh:R
Immunity
Infant, Newborn
Infant
Human Genetics
Epistasis, Genetic
medicine.disease
Asthma
Biomarker Epidemiology
Genetic marker
Genetic Polymorphism
biology.protein
Clinical Immunology
lcsh:Q
Population Genetics
Mathematics
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....1fc15f5d54fa5ecf963b8c8c5dd73e95
- Full Text :
- https://doi.org/10.1371/journal.pone.0070362