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Increased circulating levels of musclin in newly diagnosed type 2 diabetic patients
- Source :
- Diabetes and Vascular Disease Research. 14:116-121
- Publication Year :
- 2017
- Publisher :
- SAGE Publications, 2017.
-
Abstract
- Background: Musclin is a newly identified skeletal muscle–derived secretory factor, which has been recently characterized as a stimulator that induces insulin resistance in mice. However, the pathophysiological role of musclin in humans remains poorly understood. The aim of this study was to explore the potential correlations between musclin plasma levels and various metabolic parameters in patients with type 2 diabetes mellitus. Materials and methods: In this hospital-based study, plasma samples were collected from the enrolled individuals, including 38 newly diagnosed, treatment-naive type 2 diabetes mellitus patients and 41 age- and gender-matched control subjects. Plasma musclin levels were examined by radioimmunoassay. Results: Compared with the control group, musclin plasma levels were significantly higher in untreated type 2 diabetes mellitus patients. Musclin levels in the plasma of newly diagnosed type 2 diabetes mellitus patients were positively correlated with fasting plasma glucose, haemoglobin A1c, serum insulin, triglycerides and homeostasis model assessment of insulin resistance. Furthermore, multivariate logistic regression analysis showed that the level of musclin was associated with the presence of type 2 diabetes mellitus. Receiver operating characteristic curve analysis yielded an area under the curve for musclin of 0.718 in type 2 diabetes mellitus. Conclusion: The circulating concentration of musclin was significantly increased in type 2 diabetes mellitus patients. Our results suggest that musclin has a strong relationship with insulin resistance in type 2 diabetes mellitus.
- Subjects :
- Adult
Blood Glucose
Male
0301 basic medicine
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Radioimmunoassay
Muscle Proteins
Newly diagnosed
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Insulin resistance
Predictive Value of Tests
Diabetes mellitus
Internal medicine
Odds Ratio
Internal Medicine
medicine
Humans
Insulin
Triglycerides
Glycated Hemoglobin
business.industry
Type 2 Diabetes Mellitus
Skeletal muscle
Middle Aged
medicine.disease
Up-Regulation
Logistic Models
030104 developmental biology
Endocrinology
medicine.anatomical_structure
Diabetes Mellitus, Type 2
ROC Curve
Area Under Curve
Case-Control Studies
Multivariate Analysis
Linear Models
Female
Insulin Resistance
Cardiology and Cardiovascular Medicine
business
Biomarkers
Transcription Factors
Subjects
Details
- ISSN :
- 17528984 and 14791641
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Diabetes and Vascular Disease Research
- Accession number :
- edsair.doi.dedup.....1fc215167fb339267938b1768799fdfc