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Anti-CD25 Antibodies Decrease the Ability of Human Dendritic Cells to Prime Allogeneic CD4 T Cells
- Source :
- Transplantation Proceedings. 41:695-697
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- Anti-CD25 monoclonal antibodies are largely used in clinical transplantation to prevent acute allograft rejection episodes. Although their effects on T lymphocytes have been extensively studied, their impact on human dendritic cells (DCs) has been less reported. Furthermore, the role of the interleukin-2 in DC functions has not yet been fully elucidated. In this study, we observed that stimulation of human monocyte-derived DCs with lipopolysa ccharide or CD40L strongly induced the expression of CD25. We showed that pretreatment of DC with anti-CD25 diminished their ability to prime T-helper cells. In contrast, humanized anti-CD25 monoclonal antibodies did not affect the up-regulation of CD86, CD80, CD83, HLA-DR, or CD40 induced by lipopolysaccharide stimulation. This study supported previously unrecognized effects of anti-CD25 monoclonal antibodies on DCs that may contribute to their clinical efficacy.
- Subjects :
- CD4-Positive T-Lymphocytes
Graft Rejection
medicine.drug_class
CD40 Ligand
Immunoglobulins
chemical and pharmacologic phenomena
Lymphocyte Activation
Monoclonal antibody
Monocytes
Antigens, CD
medicine
Humans
Transplantation, Homologous
IL-2 receptor
CD40 Antigens
Antigen-presenting cell
CD86
Transplantation
Membrane Glycoproteins
CD40
biology
business.industry
Interleukin-2 Receptor alpha Subunit
hemic and immune systems
Dendritic Cells
HLA-DR Antigens
Dendritic cell
Antibodies, Anti-Idiotypic
Acute Disease
CD4 Antigens
Immunology
B7-1 Antigen
biology.protein
Surgery
B7-2 Antigen
business
CD80
Subjects
Details
- ISSN :
- 00411345
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Transplantation Proceedings
- Accession number :
- edsair.doi.dedup.....1fc94e78bc4ee21c7896273a65386ec7