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CCNE1 Amplification and Centrosome Number Abnormality in Serous Tubal Intraepithelial Carcinoma- Further Evidence Supporting its Role as a Precursor of Ovarian High-Grade Serous Carcinoma

Authors :
Ie Ming Shih
Ann Smith Sehdev
Kai Doberstein
Tian Li Wang
Robert J. Kurman
Elisabetta Kuhn
Ayse Ayhan
Asli Bahadirli-Talbott
Ronny Drapkin
Source :
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Publication Year :
2016

Abstract

Aberration in chromosomal structure characterizes almost all cancers and has profound biological significance in tumor development. It can be facilitated by various mechanisms including overexpression of cyclin E1 and centrosome amplification. As ovarian high-grade serous carcinoma has pronounced chromosomal instability, in this study we sought to determine whether increased copy number of CCNE1 which encodes cyclin E1 and centrosome amplification (>2 copies) occurs in its putative precursor, serous tubal intraepithelial carcinoma. We found CCNE1 copy number gain/amplification in 8 (22%) of 37 serous tubal intraepithelial carcinomas and 12 (28%) of 43 high-grade serous carcinomas. There was a correlation in CCNE1 copy number between serous tubal intraepithelial carcinoma and high-grade serous carcinoma in the same patients (P

Details

Language :
English
ISSN :
15300285 and 08933952
Volume :
29
Issue :
10
Database :
OpenAIRE
Journal :
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Accession number :
edsair.doi.dedup.....1fd12ba7b1cec8e58e69401a81048180