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Coronary Artery Calcium Assessed Years Before Was Positively Associated With Subtle White Matter Injury of the Brain in Asymptomatic Middle-Aged Men: The Framingham Heart Study
- Source :
- Circ Cardiovasc Imaging
- Publication Year :
- 2021
-
Abstract
- Background: Using magnetic resonance diffusion tensor imaging, we previously showed a cross-sectional association between carotid-femoral pulse wave velocity, a measure of aortic stiffness, and subtle white matter injury in clinically asymptomatic middle-age adults. While coronary artery calcium (CAC) is a robust measure of atherosclerosis, and a predictor of stroke and dementia, whether it predicts diffusion tensor imaging-based subtle white matter injury in the brain remains unknown. Methods: In FHS (Framingham Heart Study), an observational study, third-generation participants were assessed for CAC (2002–2005) and brain magnetic resonance imaging (2009–2014). Outcomes were diffusion tensor imaging-based measures; free water, fractional anisotropy, and peak width of mean diffusivity. After excluding the participants with neurological conditions and missing covariates, we categorized participants into 3 groups according to CAC score (0, 0 < to 100, and >100) and calculated a linear trend across the CAC groups. In secondary analyses treating CAC score as continuous, we computed slope of the outcomes per 20 to 80th percentiles higher log-transformed CAC score using linear regression. Results: In a total of 1052 individuals analyzed (mean age 45.4 years, 45.4% women), 71.6%, 22.4%, and 6.0% had CAC score of 0, 0 < to 100, and >100, respectively. We observed a significant linear trend of fractional anisotropy, but not other measures, across the CAC groups after multivariable adjustment. In the secondary analyses, CAC was associated with lower fractional anisotropy in men but not in women. Conclusions: CAC may be a promising tool to predict prevalent subtle white matter injury of the brain in asymptomatic middle-aged men.
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
Coronary Artery Disease
030204 cardiovascular system & hematology
Coronary Angiography
Asymptomatic
Risk Assessment
Article
White matter
03 medical and health sciences
0302 clinical medicine
Framingham Heart Study
Sex Factors
Leukoencephalopathies
Predictive Value of Tests
Risk Factors
Internal medicine
Multidetector Computed Tomography
medicine
Humans
Radiology, Nuclear Medicine and imaging
Vascular Calcification
Pulse wave velocity
business.industry
White Matter Injury
Age Factors
Middle Aged
Prognosis
Coronary artery calcium
medicine.anatomical_structure
Diffusion Tensor Imaging
Asymptomatic Diseases
Cardiology
Aortic stiffness
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
business
030217 neurology & neurosurgery
Diffusion MRI
Subjects
Details
- ISSN :
- 19420080
- Volume :
- 14
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Circulation. Cardiovascular imaging
- Accession number :
- edsair.doi.dedup.....1fe2a2f726f6fcd0ad3869efe85cf74c