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Anxiety Levels Predict Bone Mineral Density in Postmenopausal Women Undergoing Oral Bisphosphonates: A Two-Year Follow-Up
- Source :
- International Journal of Environmental Research and Public Health, Vol 18, Iss 8144, p 8144 (2021), Martino, G, Bellone, F, Vicario, C M, Gaudio, A, Caputo, A, Corica, F, Squadrito, G, Schwarz, P, Morabito, N & Catalano, A 2021, ' Anxiety levels predict bone mineral density in postmenopausal women undergoing oral bisphosphonates : A two-year follow-up ', International Journal of Environmental Research and Public Health, vol. 18, no. 15, 8144 . https://doi.org/10.3390/ijerph18158144, International Journal of Environmental Research and Public Health, Volume 18, Issue 15
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Clinical psychological factors may predict medical diseases. Anxiety level has been associated with osteoporosis, but its role on bone mineral density (BMD) change is still unknown. This study aimed to investigate the association between anxiety levels and both adherence and treatment response to oral bisphosphonates (BPs) in postmenopausal osteoporosis. BMD and anxiety levels were evaluated trough dual-energy X-ray absorptiometry and the Hamilton Anxiety Rating Scale (HAM-A), respectively. Participants received weekly medication with alendronate or risedronate and were grouped according to the HAM-A scores into tertiles (HAM-A 3 &gt<br />HAM-A 2 &gt<br />HAM-A 1). After 24 months, BMD changes were different among the HAM-A tertiles. The median lumbar BMD change was significantly greater in both the HAM-A 2 and HAM-A 3 in comparison with the HAM-A 1. The same trend was observed for femoral BMD change. Adherence to BPs was &gt<br />75% in 68% of patients in the HAM-A 1, 79% of patients in the HAM-A 2, and 89% of patients in the HAM-A 3 (p = 0.0014). After correcting for age, body mass index, depressive symptoms, and the 10-yr. probability of osteoporotic fractures, anxiety levels independently predicted lumbar BMD change (β = 0.3417, SE 0.145, p = 0.02). In conclusion, women with higher anxiety levels reported greater BMD improvement, highlighting that anxiety was associated with adherence and response to osteoporosis medical treatment, although further research on this topic is needed.
- Subjects :
- Hamilton Anxiety Rating Scale
fracture risk
Health, Toxicology and Mutagenesis
Osteoporosis
postmenopausal women
Anxiety
0302 clinical medicine
Bone Density
immune system diseases
hemic and lymphatic diseases
adherence
Osteoporosis, Postmenopausal
Bone mineral
Lumbar Vertebrae
Alendronate
food and beverages
virus diseases
Bisphosphonates
anxiety
Postmenopause
Medicine
Female
Postmenopausal
risedronate
clinical psychology
medicine.symptom
Risedronic Acid
medicine.medical_specialty
Fracture risk
Clinical psychology
030209 endocrinology & metabolism
Article
03 medical and health sciences
Lumbar
Internal medicine
mental disorders
medicine
Bone mineral density
Humans
bisphosphonates
Risedronate
Postmenopausal women
Oral bisphosphonates
business.industry
Public Health, Environmental and Occupational Health
alendronate
medicine.disease
osteoporosis
Adherence
Postmeno-pausal women
business
bone mineral density
Body mass index
030217 neurology & neurosurgery
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 16617827 and 16604601
- Volume :
- 18
- Issue :
- 8144
- Database :
- OpenAIRE
- Journal :
- International Journal of Environmental Research and Public Health
- Accession number :
- edsair.doi.dedup.....1ffcfc442760a57b23ceced466f20bfc