The impact of weight loss on physical function and symptoms in overweight or obese breast cancer survivors: results from POWER-remote

PURPOSE: In pre-planned observational analysis of the POWER-remote trial, we examined the impact of weight loss on patient-reported outcomes (PROs). We hypothesized a priori that survivors with ≥5% weight loss would have improved physical function (PF) at 6 months v. those who did not. METHODS: Patients with stage 0-III breast cancer who completed local therapy and chemotherapy with BMI ≥25 kg/m(2) were randomized to POWER-remote (telephone coaching; diet/activity tracking) or self-directed weight-loss (booklet). Participants completed PROs at baseline, 6 and 12 months: PROMIS PF, pain, fatigue, anxiety, depression, sleep; FACT-endocrine symptoms; MOS-sexual function. Changes in PROs among those with ≥5% weight loss v. those with