Association of retinal vessel attenuation with visual function in eyes with retinitis pigmentosa

Satoko Nakagawa, Akio Oishi, Ken Ogino, Yukiko Makiyama, Masafumi Kurimoto, Nagahisa Yoshimura Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan Purpose: To investigate the association between visual changes and retinal vessel attenuation in patients with retinitis pigmentosa (RP).Design: A retrospective, longitudinal, observational cohort study.Methods: We analyzed 45eyes from 45subjects who were followed-up for ≥3years at our clinic. Using the computer-based Interactive Vessel Analysis program, central retinal artery equivalent (CRAE) and central retinal vein equivalent (CRVE) were determined. Age- and sex-matched controls from normal subjects were selected from our archived fundus photograph library. Visual acuity, visual field area (Goldmann perimetry, V4e white test light), mean deviation (Humphrey perimetry, central 10-2program), and central macular thickness (optical coherence tomography) were analyzed for correlations with CRAE and CRVE.Results: Both CRAE and CRVE were significantly decreased in RP eyes (94.9±13.5µm and 155.6±20.0µm, respectively) compared with control eyes (138.1±14.7µm and 215.0±20.4µm, respectively, both P