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Comparison Between CKD-EPI Creatinine and MDRD Equations to Estimate Glomerular Filtration Rate in Kidney Transplant Patients
- Source :
- Transplantation proceedings. 48(2)
- Publication Year :
- 2016
-
Abstract
- The Modification of Diet in Renal Disease (MDRD) equation is widely used to estimate glomerular filtration rate (eGFR) in kidney transplant (KT) patients. The novel Chronic Kidney Disease-Epidemiology Collaboration equation (CKD-EPI) could improve accuracy of GFR estimation. Our aim was to compare both equations for staging of CKD in KT patients.In a cohort of KT patients, correlation of eGFR according to MDRD and CKD-EPI with 24-hour creatinine clearance (24h-CrCl) was evaluated. Concordance between both equations for CKD staging was performed. MDRD was used for initial CKD staging. The mean difference of GFR between 24h-CrCl and each equation was calculated and Bland-Altman analysis applied.A cohort of 463 KT patients were studied: 67% female, overall average age 46 ± 14 years, 41% living donor, mean time of transplantation 71 months (3-95), and mean serum creatinine 1.68 ± 1.03 mg/dL. For the whole cohort (all CKD stages), eGFR by CKD-EPI was 5.33 mL/min/1.73 m(2) higher than by MDRD (P .01). For CKD stages 1, 2, and 3A, the mean eGFR differences (CKD-EPI - MDRD) were 13.98 ± 3.27, 8.2 ± 1.98, and 5.34 ± 1.32 mL/min/1,73 m(2), respectively. The percentage of patients with eGFR 60 mL/min/1.73 m(2) decreased from 63.8% according to MDRD to 53.9% with the use of CKD-EPI. In women and patients ≤65 years old, eGFR by CKD-EPI was 5.98 and 5.81 mL/min/1.73 m(2) higher, respectively, than by MDRD (P .01).The novel CKD-EPI reduces the number of patients with eGFR 60 mL/min/1.73 m(2) and consequently assigns lower CKD stages to our KT population.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Concordance
Urology
Renal function
030230 surgery
urologic and male genital diseases
Kidney transplant
Risk Assessment
03 medical and health sciences
chemistry.chemical_compound
Young Adult
0302 clinical medicine
Internal medicine
medicine
Living Donors
Humans
Renal Insufficiency, Chronic
Child
Kidney transplantation
Aged
Aged, 80 and over
Transplantation
Creatinine
Kidney
business.industry
Middle Aged
medicine.disease
Kidney Transplantation
female genital diseases and pregnancy complications
medicine.anatomical_structure
Endocrinology
chemistry
Child, Preschool
Cohort
Regression Analysis
030211 gastroenterology & hepatology
Surgery
Female
business
Glomerular Filtration Rate
Subjects
Details
- ISSN :
- 18732623
- Volume :
- 48
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Transplantation proceedings
- Accession number :
- edsair.doi.dedup.....200e7fb46368458488d3af77bda9167b