Back to Search
Start Over
Assessing Associations between the AURKA-HMMR-TPX2-TUBG1 Functional Module and Breast Cancer Risk in BRCA1/2 Mutation Carriers
- Source :
- Recercat. Dipósit de la Recerca de Catalunya, instname, Blanco, I, Kuchenbaecker, K, Cuadras, D, Wang, X, Barrowdale, D, de Garibay, G R, Librado, P, Sánchez-Gracia, A, Rozas, J, Bonifaci, N, McGuffog, L, Pankratz, V S, Islam, A, Mateo, F, Berenguer, A, Petit, A, Català, I, Brunet, J, Feliubadaló, L, Tornero, E, Benítez, J, Osorio, A, Cajal, T R Y, Nevanlinna, H, Aittomäki, K, Arun, B K, Toland, A E, Karlan, B Y, Walsh, C, Lester, J, Greene, M H, Mai, P L, Nussbaum, R L, Andrulis, I L, Domchek, S M, Nathanson, K L, Rebbeck, T R, Barkardottir, R B, Jakubowska, A, Lubinski, J, Durda, K, Jaworska-Bieniek, K, Claes, K, Van Maerken, T, Díez, O, Hansen, T V, Gerdes, A-M, Bojesen, A, Thomassen, M, Kruse, T A & Teixeira 2015, ' Assessing Associations between the AURKA-HMMR-TPX2-TUBG1 Functional Module and Breast Cancer Risk in BRCA1/2 Mutation Carriers ', PLOS ONE, vol. 10, no. 4, e0120020 . https://doi.org/10.1371/journal.pone.0120020, PLoS ONE, 10(4):e0120020. PUBLIC LIBRARY SCIENCE, PLoS ONE, 10(4):e0120020. Public Library of Science, PLoS One, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, Blanco, I, Kuchenbaecker, K, Cuadras, D, Wang, X S, Barrowdale, D, Garibay, G R, Librado, P, Sanchez-Gracia, A, Rozas, J, Bonifaci, N, McGuffog, L, Pankratz, V S, Islam, A, Mateo, F, Berenguer, A, Petit, A, Catala, I, Brunet, J, Feliubadalo, L, Tornero, E, Benitez, J, Osorio, A, Cajal, T R Y, Nevanlinna, H, Aittomaki, K, Arun, B K, Toland, A E, Karlan, B Y, Walsh, C, Lester, J, Greene, M H, Mai, P L, Nussbaum, R L, Andrulis, I L, Domchek, S M, Nathanson, K L, Rebbeck, T R, Barkardottir, R B, Jakubowska, A, Lubinski, J, Durda, K, Jaworska-Bieniek, K, Claes, K, Van Maerken, T, Diez, O, Hansen, T V, Jonson, L, Gerdes, A M, Ejlertsen, B, de la Hoya, M, Caldees, T, Dunning, A M, Oliver, C, Fineberg, E, Cook, M, Peock, S, McCann, E, Murray, A, Jacobs, C, Pichert, G, Lalloo, F, Chu, C, Dorkins, H, Paterson, J, Ong, K R, Teixeira, M R, Hogervorst, F B L, van der Hout, A H, Seynaeve, C, van der Luijt, R B, Ligtenberg, M J L, Devilee, P, Wijnen, J T, Rookus, M A, Meijers-Heijboer, E J, Blok, M J, van den Ouweland, A M W, Aalfs, C M, Rodriguez, G C, Phillips, K A A, Piedmonte, M, Nerenstone, S R, Bae-Jump, V L, O'Malley, D M, Ratner, E S, Schmutzler, R K, Wappenschmidt, B, Rhiem, K, Engel, C, Meindl, A, Ditsch, N, Arnold, N, Plendl, H J, Niederacher, D, Sutter, C, Wang-Gohrke, S, Steinemann, D, Preisler-Adams, S, Antoniou, A C & Pujana, M A 2015, ' Assessing Associations between the AURKA-HMMR-TPX2-TUBG1 Functional Module and Breast Cancer Risk in BRCA1/2 Mutation Carriers ', PLoS ONE, vol. 10, no. 4, e0120020 . https://doi.org/10.1371/journal.pone.0120020, PLoS One (print), 10(4). Public Library of Science, Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid, Consejería de Sanidad de la Comunidad de Madrid, PLoS ONE; 10(4), no e0120020 (2015), Blanco, I, Kuchenbaecker, K, Cuadras, D, Wang, X, Barrowdale, D, de Garibay, G R, Librado, P, Sánchez-Gracia, A, Rozas, J, Bonifaci, N, McGuffog, L, Pankratz, V S, Islam, A, Mateo, F, Berenguer, A, Petit, A, Català, I, Brunet, J, Feliubadaló, L, Tornero, E, Benítez, J, Osorio, A, Cajal, T R Y, Nevanlinna, H, Aittomäki, K, Arun, B K, Toland, A E, Karlan, B Y, Walsh, C, Lester, J, Greene, M H, Mai, P L, Nussbaum, R L, Andrulis, I L, Domchek, S M, Nathanson, K L, Rebbeck, T R, Barkardottir, R B, Jakubowska, A, Lubinski, J, Durda, K, Jaworska-Bieniek, K, Claes, K, Van Maerken, T, Díez, O, Hansen, T V, Bojesen, A, Pedersen, I S, Sunde, L, Jensen, U B & Teixeira 2015, ' Assessing Associations between the AURKA-HMMR-TPX2-TUBG1 Functional Module and Breast Cancer Risk in BRCA1/2 Mutation Carriers ', PLOS ONE, vol. 10, no. 4, pp. e0120020 . https://doi.org/10.1371/journal.pone.0120020, PLoS ONE, 10(4), PloS one, vol 10, iss 4, PLOS ONE, 10(4):e0120020. Public Library of Science, PLoS ONE, PLoS One, 10, 4, Blanco, I, Kuchenbaecker, K, Cuadras, D, Wang, X, Barrowdale, D, de Garibay, G R, Librado, P, Sánchez-Gracia, A, Rozas, J, Bonifaci, N, McGuffog, L, Pankratz, V S, Islam, A, Mateo, F, Berenguer, A, Petit, A, Català, I, Brunet, J, Feliubadaló, L, Tornero, E, Benítez, J, Osorio, A, Cajal, T R Y, Nevanlinna, H, Aittomäki, K, Arun, B K, Toland, A E, Karlan, B Y, Walsh, C, Lester, J, Greene, M H, Mai, P L, Nussbaum, R L, Andrulis, I L, Domchek, S M, Nathanson, K L, Rebbeck, T R, Barkardottir, R B, Jakubowska, A, Lubinski, J, Durda, K, Jaworska-Bieniek, K, Claes, K, Van Maerken, T, Díez, O, Hansen, T V, Jønson, L, Gerdes, A-M, Ejlertsen, B, Pedersen, I S & Teixeira 2015, ' Assessing Associations between the AURKA-HMMR-TPX2-TUBG1 Functional Module and Breast Cancer Risk in BRCA1/2 Mutation Carriers ', PLOS ONE, vol. 10, no. 4, pp. e0120020 . https://doi.org/10.1371/journal.pone.0120020, Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, PLoS ONE, 10(4). Public Library of Science, Dipòsit Digital de la UB, Universidad de Barcelona, PLoS ONE, Vol 10, Iss 4, p e0120020 (2015), PLoS ONE [E], 10(4). Public Library of Science, PLOS ONE, PLoS One, 10
- Publication Year :
- 2015
-
Abstract
- While interplay between BRCA1 and AURKA-RHAMM-TPX2-TUBG1 regulates mammary epithelial polarization, common genetic variation in HMMR (gene product RHAMM) may be associated with risk of breast cancer in BRCA1 mutation carriers. Following on these observations, we further assessed the link between the AURKA-HMMR-TPX2-TUBG1 functional module and risk of breast cancer in BRCA1 or BRCA2 mutation carriers. Forty-one single nucleotide polymorphisms (SNPs) were genotyped in 15,252 BRCA1 and 8,211 BRCA2 mutation carriers and subsequently analyzed using a retrospective likelihood approach. The association of HMMR rs299290 with breast cancer risk in BRCA1 mutation carriers was confirmed: per-allele hazard ratio (HR) = 1.10, 95% confidence interval (CI) 1.04 - 1.15, p = 1.9 x 10(-4) (false discovery rate (FDR)-adjusted p = 0.043). Variation in CSTF1, located next to AURKA, was also found to be associated with breast cancer risk in BRCA2 mutation carriers: rs2426618 per-allele HR = 1.10, 95% CI 1.03 - 1.16, p = 0.005 (FDR-adjusted p = 0.045). Assessment of pairwise interactions provided suggestions (FDR-adjusted p(interaction) values greater than 0.05) for deviations from the multiplicative model for rs299290 and CSTF1 rs6064391, and rs299290 and TUBG1 rs11649877 in both BRCA1 and BRCA2 mutation carriers. Following these suggestions, the expression of HMMR and AURKA or TUBG1 in sporadic breast tumors was found to potentially interact, influencing patients survival. Together, the results of this study support the hypothesis of a causative link between altered function of AURKA-HMMR-TPX2-TUBG1 and breast carcinogenesis in BRCA1/2 mutation carriers. Funding Agencies|National Cancer Institute [UM1 CA164920]; Lithuania (BFBOCC-LT): Research Council of Lithuania grant [LIG-07/2012]; Hereditary Cancer Association (Paveldimo vezio asociacija); LSC grant [10.0010.08]; ESF [2009/0220/1DP/1.1.1.2.0/09/APIA/VIAA/016]; Liepajas municipal council; Cancer Association of South Africa (CANSA); Morris and Horowitz Familes Endowed Professorship; NEYE Foundation; Spanish Association against Cancer [AECC08, RTICC 06/0020/1060, FISPI08/1120]; Mutua Madrilena Foundation (FMMA); COH-CCGCRN: City of Hope Clinical Cancer Genetics Community Network from the National Cancer Institute and the Office of the Director, National Institutes of Health; Hereditary Cancer Research Registry from the National Cancer Institute and the Office of the Director, National Institutes of Health [RC4CA153828]; Fondazione IRCCS Istituto Nazionale Tumori; Cancer Research-United Kingdom grant [C12292/A11174, C1287/ A10118]; NHMRC Program Grant; DKFZ; European Union (European Social Fund-ESF); Greek national funds through the Operational Program "Education and Lifelong Learning" of the National Strategic Reference Framework (NSRF)-Research Funding Program of the General Secretariat for Research and Technology: ARISTEIA; European Social Fund; Cancer Research United Kingdom Grants [C1287/A10118, C1287/A11990]; National Institute of Health Research (NIHR) grant; NIHR grant; Royal Marsden NHS Foundation Trust; Cancer Research United Kingdom Grant [C5047/A8385]; University of Kansas Cancer Center [P30 CA168524]; Kansas Bioscience Authority Eminent Scholar Program; Chancellors Distinguished Chair in Biomedical Sciences Professorship; AKG [5U01CA113916, R01CA140323]; German Cancer Aid [109076]; Center for Molecular Medicine Cologne (CMMC); Ligue National Contre le Cancer; Association "Le cancer du sein, parlonsen!" Award; Canadian Institutes of Health Research; Fund for Scientific Research Flanders (FWO); National Cancer Institute grant [CA 27469]; GOG Statistical and Data Center [CA 37517]; GOGs Cancer Prevention and Control Committee [CA 101165]; Intramural Research Program, NCI; ISCIII (Spain) [RD12/00369/0006, 12/00539]; European Regional Development FEDER funds; Helsinki University Central Hospital Research Fund; Academy of Finland [132473]; Finnish Cancer Society; Sigrid Juselius Foundation; Dutch Cancer Society grant [NKI1998-1854, NKI2004-3088, NKI2007-3756]; Netherlands Organization of Scientific Research [NWO 91109024]; Pink Ribbon grant [110005]; BBMRI grant [NWO 184.021.007/CP46]; Hungarian Research Grant [KTIA-OTKA CK-80745]; Norwegian EEA Financial Mechanism [HU0115/NA/2008-3/OP-9]; Spanish Ministry of Health ISCIII FIS [PI10/01422, PI12/01528, PI13/00285]; RTICC [RD12/0036/0008]; Ramon Areces (XV) Foundation; Eugenio Rodriguez Pascual Foundation; Roses Contra el Cancer Foundation; Spanish Association Against Cancer (AECC); AGAUR Generalitat de Catalunya [2009-SGR290, 2009-SGR293]; Polish Foundation of Science; Icelandic Association "Walking for Breast Cancer Research"; Nordic Cancer Union; Landspitali University Hospital Research Fund; Canadian Institutes of Health Research for the "CIHR Team in Familial Risks of Breast Cancer" program; Canadian Breast Cancer Research Alliance-grant [019511]; Ministry of Economic Development, Innovation and Export Trade-grant [PSR-SIIRI-701]; Ministero dellIstruzione, dellUniversita e della Ricerca and Ministero della Salute; Liga Portuguesa Contra o Cancro; National Breast Cancer Foundation; National Health and Medical Research Council (NHMRC); Queensland Cancer Fund; Cancer Council of New South Wales; Cancer Council of Victoria; Cancer Foundation of Western Australia; Cancer Councils of Tasmania; National Institutes of Health grant [CA128978]; NCI Specialized Program of Research Excellence (SPORE) in Breast Cancer [CA116201]; United States Department of Defence Ovarian Cancer Idea award [W81XWH-10-1-0341]; Breast Cancer Research Foundation; Jewish General Hospital Weekend; Quebec Ministry of Economic Development, Innovation and Export Trade; Cancer Councils of South Australia; European Regional Development Fund; State Budget of the Czech Republic (RECAMO) [CZ.1.05/2.1.00/03.0101]; MH CZ-DRO (MMCI) [00209805]; Niehaus Family Genetics Research Fund; STARR Cancer Consortium Grant; NAROD [1R01 CA149429-01]; NCI Intramural Research Program, National Institutes of Health [NO2-CP-11019-50, N02-CP-65504]; Westat, Inc, Rockville, Maryland; Clalit Health Services in Israel; Israel Cancer Association; Breast Cancer Research Foundation (BCRF), New York; Russian Federation for Basic Research [11-04-00227, 12-04-00928, 12-04-01490]; Federal Agency for Science and Innovations, Russia [02.740.11.0780]; Canadian Institutes of Health Research for the "CIHR Team in Familial Risks of Breast Cancer" program and grant from the National Cancer Institute [UM1 CA164920]; Breast Cancer Family Registry (BCFR); United States Government or the BCFR; Ohio State University Comprehensive Cancer Center; Isreal cancer association; Israeli Inherited breast cancer consortium; Swedish Cancer Society; Ralph and Marion Falk Medical Research Trust; Entertainment Industry Fund National Womens Cancer Research Alliance; National Institutes of Health (NIH) [R01-CA102776, R01-CA083855]; Rooney Family Foundation; Susan G. Komen Foundation for the cure, Basser Research Center; American Cancer Society Early Detection Professorship [SIOP-06-258-01-COUN]; SAF2010-20493; [PBZ_KBN_122/P05/2004]
- Subjects :
- single nucleotide
Oncology
Carcinogenesis
TUBG1
Genes, BRCA2
Genes, BRCA1
Càncer d'ovari
MODIFIERS
Genome-wide association study
Cell Cycle Proteins
Breast cancer
mammary glands
Aetiology
genes
skin and connective tissue diseases
Cancer
Extracellular Matrix Proteins
Hazard ratio
CHIP-SEQ
3. Good health
ddc
Hyaluronan Receptors
Medicine
Teixeira
Human
medicine.medical_specialty
Evolution
Science
Non-P.H.S
Single-nucleotide polymorphism
Evolution, Molecular
SDG 3 - Good Health and Well-being
Ovarian cancer
Genetics
biochemistry
Humans
human
CELL
Polymorphism
GENOME-WIDE ASSOCIATION
medicine (all)
Retrospective Studies
Cancer och onkologi
Prevention
Mutació (Biologia)
Biology and Life Sciences
Molecular
SWE-BRCA
BRCA1
medicine.disease
BRCA2
POLYMORPHISM
Genes
Genetic Loci
Cancer and Oncology
Mutation
U.S. Gov't
Bioinformatics
medicine.disease_cause
3123 Gynaecology and paediatrics
Tubulin
Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14]
ELEMENTS
2.1 Biological and endogenous factors
CD44
Non-U.S. Gov't
Aurora Kinase A
Likelihood Functions
Multidisciplinary
Research Support, Non-U.S. Gov't
agricultural and biological sciences (all)
genetics and molecular biology (all)
BCFR
Nuclear Proteins
Single Nucleotide
Mammary Glands
SURVIVAL
kConFab Investigators
Female
Microtubule-Associated Proteins
Research Article
Antigens, CD44
aurora kinase A
breast neoplasms
carcinogenesis
cell cycle proteins
estrogen receptor alpha
evolution, molecular
extracellular matrix proteins
female
genetic loci
genetic predisposition to disease
humans
likelihood functions
mammary glands, human
microtubule-associated proteins
nuclear proteins
polymorphism
retrospective studies
tubulin
genes, BRCA1
genes, BRCA2
mutation
biochemistry, genetics and molecular biology (all)
SUSCEPTIBILITY LOCI
General Science & Technology
3122 Cancers
Breast Neoplasms
Biology
Research Support
Polymorphism, Single Nucleotide
N.I.H
GENETIC INTERACTION NETWORKS
Càncer de mama
EXPRESSION SIGNATURE
Amino acid sequence
Research Support, N.I.H., Extramural
Internal medicine
Seqüència d'aminoàcids
evolution
Genetic variation
Journal Article
medicine
Genetic Predisposition to Disease
ddc:610
molecular
Antigens
Mammary Glands, Human
ddc:611
Intramural
Estrogen Receptor alpha
Extramural
Mutation (Biology)
Research Support, N.I.H., Intramural
3111 Biomedicine
GEMO
Research Support, U.S. Gov't, Non-P.H.S
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Database :
- OpenAIRE
- Journal :
- Recercat. Dipósit de la Recerca de Catalunya, instname, Blanco, I, Kuchenbaecker, K, Cuadras, D, Wang, X, Barrowdale, D, de Garibay, G R, Librado, P, Sánchez-Gracia, A, Rozas, J, Bonifaci, N, McGuffog, L, Pankratz, V S, Islam, A, Mateo, F, Berenguer, A, Petit, A, Català, I, Brunet, J, Feliubadaló, L, Tornero, E, Benítez, J, Osorio, A, Cajal, T R Y, Nevanlinna, H, Aittomäki, K, Arun, B K, Toland, A E, Karlan, B Y, Walsh, C, Lester, J, Greene, M H, Mai, P L, Nussbaum, R L, Andrulis, I L, Domchek, S M, Nathanson, K L, Rebbeck, T R, Barkardottir, R B, Jakubowska, A, Lubinski, J, Durda, K, Jaworska-Bieniek, K, Claes, K, Van Maerken, T, Díez, O, Hansen, T V, Gerdes, A-M, Bojesen, A, Thomassen, M, Kruse, T A & Teixeira 2015, ' Assessing Associations between the AURKA-HMMR-TPX2-TUBG1 Functional Module and Breast Cancer Risk in BRCA1/2 Mutation Carriers ', PLOS ONE, vol. 10, no. 4, e0120020 . https://doi.org/10.1371/journal.pone.0120020, PLoS ONE, 10(4):e0120020. PUBLIC LIBRARY SCIENCE, PLoS ONE, 10(4):e0120020. Public Library of Science, PLoS One, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, Blanco, I, Kuchenbaecker, K, Cuadras, D, Wang, X S, Barrowdale, D, Garibay, G R, Librado, P, Sanchez-Gracia, A, Rozas, J, Bonifaci, N, McGuffog, L, Pankratz, V S, Islam, A, Mateo, F, Berenguer, A, Petit, A, Catala, I, Brunet, J, Feliubadalo, L, Tornero, E, Benitez, J, Osorio, A, Cajal, T R Y, Nevanlinna, H, Aittomaki, K, Arun, B K, Toland, A E, Karlan, B Y, Walsh, C, Lester, J, Greene, M H, Mai, P L, Nussbaum, R L, Andrulis, I L, Domchek, S M, Nathanson, K L, Rebbeck, T R, Barkardottir, R B, Jakubowska, A, Lubinski, J, Durda, K, Jaworska-Bieniek, K, Claes, K, Van Maerken, T, Diez, O, Hansen, T V, Jonson, L, Gerdes, A M, Ejlertsen, B, de la Hoya, M, Caldees, T, Dunning, A M, Oliver, C, Fineberg, E, Cook, M, Peock, S, McCann, E, Murray, A, Jacobs, C, Pichert, G, Lalloo, F, Chu, C, Dorkins, H, Paterson, J, Ong, K R, Teixeira, M R, Hogervorst, F B L, van der Hout, A H, Seynaeve, C, van der Luijt, R B, Ligtenberg, M J L, Devilee, P, Wijnen, J T, Rookus, M A, Meijers-Heijboer, E J, Blok, M J, van den Ouweland, A M W, Aalfs, C M, Rodriguez, G C, Phillips, K A A, Piedmonte, M, Nerenstone, S R, Bae-Jump, V L, O'Malley, D M, Ratner, E S, Schmutzler, R K, Wappenschmidt, B, Rhiem, K, Engel, C, Meindl, A, Ditsch, N, Arnold, N, Plendl, H J, Niederacher, D, Sutter, C, Wang-Gohrke, S, Steinemann, D, Preisler-Adams, S, Antoniou, A C & Pujana, M A 2015, ' Assessing Associations between the AURKA-HMMR-TPX2-TUBG1 Functional Module and Breast Cancer Risk in BRCA1/2 Mutation Carriers ', PLoS ONE, vol. 10, no. 4, e0120020 . https://doi.org/10.1371/journal.pone.0120020, PLoS One (print), 10(4). Public Library of Science, Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid, Consejería de Sanidad de la Comunidad de Madrid, PLoS ONE; 10(4), no e0120020 (2015), Blanco, I, Kuchenbaecker, K, Cuadras, D, Wang, X, Barrowdale, D, de Garibay, G R, Librado, P, Sánchez-Gracia, A, Rozas, J, Bonifaci, N, McGuffog, L, Pankratz, V S, Islam, A, Mateo, F, Berenguer, A, Petit, A, Català, I, Brunet, J, Feliubadaló, L, Tornero, E, Benítez, J, Osorio, A, Cajal, T R Y, Nevanlinna, H, Aittomäki, K, Arun, B K, Toland, A E, Karlan, B Y, Walsh, C, Lester, J, Greene, M H, Mai, P L, Nussbaum, R L, Andrulis, I L, Domchek, S M, Nathanson, K L, Rebbeck, T R, Barkardottir, R B, Jakubowska, A, Lubinski, J, Durda, K, Jaworska-Bieniek, K, Claes, K, Van Maerken, T, Díez, O, Hansen, T V, Bojesen, A, Pedersen, I S, Sunde, L, Jensen, U B & Teixeira 2015, ' Assessing Associations between the AURKA-HMMR-TPX2-TUBG1 Functional Module and Breast Cancer Risk in BRCA1/2 Mutation Carriers ', PLOS ONE, vol. 10, no. 4, pp. e0120020 . https://doi.org/10.1371/journal.pone.0120020, PLoS ONE, 10(4), PloS one, vol 10, iss 4, PLOS ONE, 10(4):e0120020. Public Library of Science, PLoS ONE, PLoS One, 10, 4, Blanco, I, Kuchenbaecker, K, Cuadras, D, Wang, X, Barrowdale, D, de Garibay, G R, Librado, P, Sánchez-Gracia, A, Rozas, J, Bonifaci, N, McGuffog, L, Pankratz, V S, Islam, A, Mateo, F, Berenguer, A, Petit, A, Català, I, Brunet, J, Feliubadaló, L, Tornero, E, Benítez, J, Osorio, A, Cajal, T R Y, Nevanlinna, H, Aittomäki, K, Arun, B K, Toland, A E, Karlan, B Y, Walsh, C, Lester, J, Greene, M H, Mai, P L, Nussbaum, R L, Andrulis, I L, Domchek, S M, Nathanson, K L, Rebbeck, T R, Barkardottir, R B, Jakubowska, A, Lubinski, J, Durda, K, Jaworska-Bieniek, K, Claes, K, Van Maerken, T, Díez, O, Hansen, T V, Jønson, L, Gerdes, A-M, Ejlertsen, B, Pedersen, I S & Teixeira 2015, ' Assessing Associations between the AURKA-HMMR-TPX2-TUBG1 Functional Module and Breast Cancer Risk in BRCA1/2 Mutation Carriers ', PLOS ONE, vol. 10, no. 4, pp. e0120020 . https://doi.org/10.1371/journal.pone.0120020, Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, PLoS ONE, 10(4). Public Library of Science, Dipòsit Digital de la UB, Universidad de Barcelona, PLoS ONE, Vol 10, Iss 4, p e0120020 (2015), PLoS ONE [E], 10(4). Public Library of Science, PLOS ONE, PLoS One, 10
- Accession number :
- edsair.doi.dedup.....200f10418f597c33c5c50d9fda5c60a2