Back to Search
Start Over
Altered microbiota by a high-fat diet accelerates lethal myeloid hematopoiesis associated with systemic SOCS3 deficiency
- Source :
- iScience, Vol 24, Iss 10, Pp 103117-(2021), iScience
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Summary The suppressors of cytokine signaling (SOCS) proteins are negative regulators of cytokine signaling required to prevent excessive cellular responses. In particular, SOCS3 is involved in the regulation of metabolic syndromes, such as obesity and diabetes, by suppressing leptin and insulin signals. SOCS3 also suppresses the inflammatory response associated with metabolic stress, but this specific role remains undefined. Wild-type mice on a high-fat diet (HFD) exhibited only fatty liver, whereas systemic deletion of SOCS3 resulted in excessive myeloid hematopoiesis and hepatic inflammation. In addition, depletion of the gut microbiota resulted in considerable improvement in excess granulopoiesis and splenomegaly, halting the progression of systemic inflammation in SOCS3KO mice on the HFD. This result suggests that intestinal dysbiosis is involved in inflammation associated with SOCS3KO. Although contributing to diet-induced obesity and fatty liver, SOCS3 is nevertheless critical to suppress excess myeloid hematopoiesis and severe systemic inflammation associated with intestinal dysbiosis on HFD.<br />Graphical abstract<br />Highlights • SOCS3 suppresses severe systemic inflammation associated with high-fat diet • SOCS3 deficiency on high-fat diet accelerates excess myeloid hematopoiesis • SOCS3 controls gut dysbiosis on high-fat diet<br />Immunology; Microbiome
- Subjects :
- Multidisciplinary
Myeloid
biology
business.industry
medicine.medical_treatment
Science
Fatty liver
digestive, oral, and skin physiology
microbiome
Inflammation
Gut flora
biology.organism_classification
medicine.disease
Systemic inflammation
Granulopoiesis
Article
immunology
medicine.anatomical_structure
Cytokine
Immunology
Medicine
SOCS3
medicine.symptom
business
Subjects
Details
- Language :
- English
- ISSN :
- 25890042
- Volume :
- 24
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- iScience
- Accession number :
- edsair.doi.dedup.....2011a8258473e039ba89c66cd5ec89d2