Scaffold Hopping Strategy to Identify Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy

Authors :: Wei Wang
Jiacheng He
Junjie Yang
Chan Zhang
Zhiyuan Cheng
Yao Zhang
Qiansen Zhang
Peili Wang
Shuowen Tang
Xin Wang
Mingyao Liu
Weiqiang Lu
Han-Kun Zhang
Source :: Journal of medicinal chemistry. 65(11)
Publication Year :: 2022
Abstract: Cancer cells can effectively suppress the natural immune response in humans, and prostaglandin E

Subjects :: Mice
Drug Discovery
Colonic Neoplasms
Tumor Microenvironment
Molecular Medicine
Animals
Immunotherapy
Receptors, Prostaglandin E, EP2 Subtype
Receptors, Prostaglandin E, EP4 Subtype
Dinoprostone

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