Back to Search
Start Over
Diagnostic role of cytology in serous effusions of patients with hematologic malignancies
- Source :
- Diagnostic Cytopathology. 47:404-411
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Background We investigated serous effusions occurring during the course of an already known hematologic neoplasia or as a first manifestation of it. We correlated cytology results with flow cytometry results, when available. In the absence of flow cytometry, our correlation was based on clinical follow up information obtained retrospectively. We evaluated our results in relation to the data of the literature and we considered some new suggestions for the improvement of cytology service. Methods Serous effusions in hematologic patients were retrieved from the files of the Department of Cytology, Laiko Hospital, for a period of 2 years. All patients had enrolled either a previous hematologic history, or a suspicious clinical and imaging status. Seventy-three serous effusions were included. Cytology reports consisting of morphology and immunocytochemistry assessment were correlated to flow cytometry results and, occasionally, to clinical follow-up. Results In the group of patients with previous history, sensitivity was 82.76%, positive predictive value was 100%, specificity 100%, and negative predictive value was 58.33%. In the group of patients without previous history, sensitivity and positive predictive value were both 91%, whereas specificity and negative predictive value could not be estimated. Conclusion We provide evidence that the diagnostic accuracy of cytology with the adjunct of immunocytochemistry is high compared to flow cytometry for detecting hematologic malignancies. In order to improve clinical performance, it is suggested that a cytology triage of serous effusions in all patients with hematologic malignancy must be implemented.
- Subjects :
- Adult
Male
medicine.medical_specialty
Histology
Lymphoma
030209 endocrinology & metabolism
Diagnostic accuracy
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Cytology
medicine
Hematologic malignancy
Ascitic Fluid
Humans
Aged
Leukemia
business.industry
Clinical performance
General Medicine
Middle Aged
Flow Cytometry
Predictive value
Pleural Effusion
Serous fluid
Hematologic Neoplasms
030220 oncology & carcinogenesis
Pericardial Fluid
Female
Radiology
business
Subjects
Details
- ISSN :
- 10970339 and 87551039
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Diagnostic Cytopathology
- Accession number :
- edsair.doi.dedup.....20168aa885a50e1973d161d7a90e1f5b