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Resveratrol Adjunct Therapy for Negative Symptoms in Patients With Stable Schizophrenia: A Double-Blind, Randomized Placebo-Controlled Trial
- Source :
- International Journal of Neuropsychopharmacology
- Publication Year :
- 2020
- Publisher :
- Oxford University Press, 2020.
-
Abstract
- Background Patients with schizophrenia can generally manifest a broad variety of primary negative symptoms. The current study aimed to assess the efficacy and tolerability of resveratrol add-on therapy in the treatment of negative symptoms in patients with stable schizophrenia. Methods In a randomized, double-blind, and placebo-controlled setting, schizophrenia patients were assigned to receive either 200 mg/d resveratrol or matched placebo in addition to a stable dose of risperidone for 8 weeks. Patients were assessed using the positive and negative syndrome scale, the extrapyramidal symptom rating scale, and Hamilton Depression Rating Scale over the trial period. The primary outcome was considered as the change in positive and negative subscale score from baseline to week 8 between the treatment arms. Results A total 52 patients completed the trial (26 in each arm). Baseline characteristics of both groups were statistically similar (P > .05). Despite the statistically similar behavior of positive symptoms between the groups across time (Greenhouse-Geisser corrected: F = 1.76, df = 1.88, P = .180), the resveratrol group demonstrated greater improvement in negative, general psychopathology, and total scores (Greenhouse-Geisser corrected: F = 12.25, df = 2.04, P Conclusion Adding resveratrol to risperidone can exhibit remarkable efficacy and safety in terms of management of schizophrenia-related negative symptoms.
- Subjects :
- Adult
Male
medicine.medical_specialty
AcademicSubjects/MED00415
Placebo-controlled study
resveratrol
Placebo
Regular Research Articles
Antioxidants
Extrapyramidal symptoms
Double-Blind Method
Internal medicine
Outcome Assessment, Health Care
medicine
Humans
Pharmacology (medical)
Pharmacology
Risperidone
Positive and Negative Syndrome Scale
business.industry
AcademicSubjects/SCI01870
primary negative symptoms
clinical trial
Middle Aged
medicine.disease
Clinical trial
schizophrenia
Psychiatry and Mental health
Tolerability
Schizophrenia
Drug Therapy, Combination
Female
medicine.symptom
business
medicine.drug
Antipsychotic Agents
Subjects
Details
- Language :
- English
- ISSN :
- 14695111 and 14611457
- Volume :
- 23
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- International Journal of Neuropsychopharmacology
- Accession number :
- edsair.doi.dedup.....20187337e40c32d88077ffb88a5d43ad