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Hispanic ethnicity is associated with prolonged clearance of high dose methotrexate and severe nephrotoxicity in children and adolescents with acute lymphoblastic leukemia
- Source :
- Leukemialymphoma. 61(11)
- Publication Year :
- 2020
-
Abstract
- Methotrexate, a competitive inhibitor of dihydrofolate reductase, is an integral part of treatment for childhood leukemia. High-dose methotrexate (HDMTX) significantly improves survival in NCI-Rome...
- Subjects :
- Oncology
Cancer Research
medicine.medical_specialty
Childhood leukemia
Adolescent
Lymphoblastic Leukemia
Nephrotoxicity
03 medical and health sciences
0302 clinical medicine
Internal medicine
Dihydrofolate reductase
medicine
Ethnicity
Humans
Renal Insufficiency
Child
biology
business.industry
Infant
Hematology
Hispanic or Latino
Precursor Cell Lymphoblastic Leukemia-Lymphoma
medicine.disease
High dose methotrexate
Methotrexate
030220 oncology & carcinogenesis
biology.protein
Hispanic ethnicity
business
Competitive inhibitor
030215 immunology
medicine.drug
Subjects
Details
- ISSN :
- 10292403
- Volume :
- 61
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Leukemialymphoma
- Accession number :
- edsair.doi.dedup.....201a1723a8bb3d7054fea622c0bdb5a5