Supplementary Figure 4 from Combined EGFR/MEK Inhibition Prevents the Emergence of Resistance in EGFR-Mutant Lung Cancer

Supplementary Figure S4. PC9 GR4 xenograft response to W+T treatment. Mice were treated with two doses (A) or four doses (B) of WZ4002, trametinib or a combination thereof. Tumors were lysed, subjected to immunoblot and phosphorylation of EGFR, AKT, ERK1/2 and S6 were assessed. Hsp90 was used as a loading control. (C) Mice were photographed 31 days following cessation of drug treatment.