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Environmental Factors Associated with Altered Gut Microbiota in Children with Eczema: A Systematic Review

Authors :
Janet W H Sit
Winnie P.Y. Tang
Cho Lee Wong
Stephen Kwok-Wing Tsui
Rosa S. Wong
Carmen W.H. Chan
Patrick Tik Wan Law
Source :
International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 17, Iss 7, p 1147 (2016)
Publication Year :
2016
Publisher :
MDPI, 2016.

Abstract

Eczema is a common skin condition that impairs children’s daily life activities and quality of life. Previous research shows that gut microbiome composition plays an important role in the development of eczema. The present review summarizes evidence on environmental factors related to altered gut microbiota in children with eczema. We searched Medline, PubMed, Embase, and the Cochrane database of Systematic Reviews through October 2015. The search strategy focused on articles published in peer-reviewed, English-language journals with no publication year limit. Only original studies and review articles that reported environmental factors on gut microbiome specific to eczema were included in this review. We selected six studies (total 1990 participants) for full review and identified that the composition of gut microbiota specific to eczema could be influenced by the following environmental factors: length of gestation, mode of delivery, type of feeding, method of treatment, number of older siblings, and other lifestyle factors. There has been inconsistent empirical evidence as to the modulatory effects of gut microbiota on immunological functions in children with eczema. Further research on the environmental-host-microbial interaction is needed to develop a strong base of knowledge for the development and implementation of prevention strategies and policies for eczema.

Details

Language :
English
ISSN :
14220067
Volume :
17
Issue :
7
Database :
OpenAIRE
Journal :
International Journal of Molecular Sciences
Accession number :
edsair.doi.dedup.....202cdeb2acff22058e5c1fae8cc7b6a3