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Environmental Factors Associated with Altered Gut Microbiota in Children with Eczema: A Systematic Review
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 17, Iss 7, p 1147 (2016)
- Publication Year :
- 2016
- Publisher :
- MDPI, 2016.
-
Abstract
- Eczema is a common skin condition that impairs children’s daily life activities and quality of life. Previous research shows that gut microbiome composition plays an important role in the development of eczema. The present review summarizes evidence on environmental factors related to altered gut microbiota in children with eczema. We searched Medline, PubMed, Embase, and the Cochrane database of Systematic Reviews through October 2015. The search strategy focused on articles published in peer-reviewed, English-language journals with no publication year limit. Only original studies and review articles that reported environmental factors on gut microbiome specific to eczema were included in this review. We selected six studies (total 1990 participants) for full review and identified that the composition of gut microbiota specific to eczema could be influenced by the following environmental factors: length of gestation, mode of delivery, type of feeding, method of treatment, number of older siblings, and other lifestyle factors. There has been inconsistent empirical evidence as to the modulatory effects of gut microbiota on immunological functions in children with eczema. Further research on the environmental-host-microbial interaction is needed to develop a strong base of knowledge for the development and implementation of prevention strategies and policies for eczema.
- Subjects :
- 0301 basic medicine
MEDLINE
Eczema
Review
Biology
Gut flora
microbiome diversity
environmental-host-microbial interaction
Catalysis
lcsh:Chemistry
Inorganic Chemistry
03 medical and health sciences
0302 clinical medicine
Quality of life (healthcare)
Environmental health
Humans
030212 general & internal medicine
Physical and Theoretical Chemistry
Child
lcsh:QH301-705.5
Molecular Biology
Spectroscopy
gut microbiota
Organic Chemistry
Gastrointestinal Microbiome
General Medicine
Environmental exposure
Environmental Exposure
biology.organism_classification
allergy development
Computer Science Applications
gene-environment interaction
Gastrointestinal Tract
immune system
030104 developmental biology
Systematic review
Lifestyle factors
Mode of delivery
lcsh:Biology (General)
lcsh:QD1-999
Immunology
childhood eczema
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 17
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....202cdeb2acff22058e5c1fae8cc7b6a3