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Confirmatory Analysis of Per and Polyfluoroalkyl Substances in Milk and Infant Formula Using UHPLC–MS/MS
- Source :
- Molecules, Vol 26, Iss 3664, p 3664 (2021), Molecules, Volume 26, Issue 12
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- An ultra-high performance liquid chromatography tandem mass spectrometry method was developed and validated for the sensitive determination and unambiguous confirmation of residues of per and polyfluorinated alkyl substances (PFAS) in breastmilk, retail milk and infant formulas following two sample preparation methods. Sample pre-treatment was carried out by a simplified QuEChERS method without requiring dSPE or any further clean-up. The method was validated in accordance with the requirements of Commission Decision 657/2002/EC with slight modifications. The method displayed good linearity with R2 ranging from 0.9843–0.9998 for all target PFAS. The recovery and within-laboratory reproducibility of the method (n = 63) were in the range 60–121% and 5–28%, respectively. The decision limit, detection capability and limit of quantitation ranged from 30–60 ng kg−1 to 40–100 ng kg−1 and 5–50 ng kg−1, respectively. Acceptable matrix effect values in the range −45–29% were obtained with uncertainty of measurement lower than 25% for all target PFAS. The method displays its suitability for the sensitive and high-throughput confirmatory analysis of C4–C14 PFAS in breastmilk, dairy milk and infant formulas.
- Subjects :
- Adult
QuEChERS
Pharmaceutical Science
Organic chemistry
UHPLC–MS/MS
breastmilk
010501 environmental sciences
Quechers
01 natural sciences
Uhplc ms ms
Article
Analytical Chemistry
South Africa
QD241-441
Liquid chromatography–mass spectrometry
Tandem Mass Spectrometry
Drug Discovery
Animals
Humans
Physical and Theoretical Chemistry
confirmatory
Chromatography, High Pressure Liquid
0105 earth and related environmental sciences
Detection limit
Reproducibility
Fluorocarbons
Chromatography
Milk, Human
Chemistry
retail milk
010401 analytical chemistry
Solid Phase Extraction
Infant, Newborn
Reproducibility of Results
infant formula
Confirmatory factor analysis
liquid–liquid extraction
0104 chemical sciences
Milk
Infant formula
Chemistry (miscellaneous)
Molecular Medicine
Female
Decision limit
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 26
- Issue :
- 3664
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....2037933eda01bcceacb970bd8711cd29