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The impact of physical frailty on the response to inactivated influenza vaccine in older adults
- Source :
- Aging (Albany NY)
- Publication Year :
- 2020
- Publisher :
- Impact Journals, LLC, 2020.
-
Abstract
- Physical frailty’s impact on hemagglutination inhibition antibody titers (HAI) and peripheral blood mononuclear cell (PBMC) transcriptional responses after influenza vaccination is unclear. Physical frailty was assessed using the 5-item Fried frailty phenotype in 168 community- and assisted-living adults ≥55 years of age during an observational study. Blood was drawn before, 3, 7, and 28 days post-vaccination with the 2017-2018 inactivated influenza vaccine. HAI response to the A/H1N1 strain was measured at Days 0 and 28 using seropositivity, seroconversion, log2 HAI titers, and fold-rise in log2 HAI titers. RNA sequencing of PBMCs from Days 0, 3 and 7 was measured in 28 participants and compared using pathway analyses. Frailty was not significantly associated with any HAI outcome in multivariable models. Compared with non-frail participants, frail participants expressed decreased cell proliferation, metabolism, antibody production, and interferon signaling genes. Conversely, frail participants showed elevated gene expression in IL-8 signaling, T-cell exhaustion, and oxidative stress pathways compared with non-frail participants. These results suggest that reduced effectiveness of influenza vaccine among older, frail individuals may be attributed to immunosenescence-related changes in PBMCs that are not reflected in antibody levels.
- Subjects :
- Male
Aging
Influenza vaccine
T-Lymphocytes
frailty
Peripheral blood mononuclear cell
immune response
Immune system
Assisted Living Facilities
Influenza, Human
peripheral cell mediated immunity
Humans
Medicine
Seroconversion
Aged
Cell Proliferation
Aged, 80 and over
Hemagglutination assay
business.industry
Interleukin-8
Antibody titer
virus diseases
Cell Biology
Hemagglutination Inhibition Tests
Middle Aged
Vaccination
Oxidative Stress
Titer
Vaccines, Inactivated
Influenza Vaccines
Case-Control Studies
Antibody Formation
Immunology
Leukocytes, Mononuclear
Female
Independent Living
Interferons
antibody titers
influenza
business
Research Paper
Subjects
Details
- ISSN :
- 19454589
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Aging
- Accession number :
- edsair.doi.dedup.....203de3cd3393beeaa559b0ca0168b822