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Multitarget Transcranial Electrical Stimulation for Freezing of Gait: A Randomized Controlled Trial
- Source :
- Movement Disorders. 36:2693-2698
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Background Treatments of freezing of gait (FOG) in Parkinson's disease are suboptimal. Objective The aim of this study was to evaluate the effects of multiple sessions of transcranial direct current stimulation (tDCS) targeting the left dorsolateral prefrontal cortex and primary motor cortex (M1) on FOG. Methods Seventy-seven individuals with Parkinson's disease and FOG were enrolled in a double-blinded randomized trial. tDCS and sham interventions comprised 10 sessions over 2 weeks followed by five once-weekly sessions. FOG-provoking test performance (primary outcome), functional outcomes, and self-reported FOG severity were assessed. Results Primary analyses demonstrated no advantage for tDCS in the FOG-provoking test. In secondary analyses, tDCS, compared with sham, decreased self-reported FOG severity and increased daily living step counts. Among individuals with mild-to-moderate FOG severity, tDCS improved FOG-provoking test time and self-report of FOG. Conclusions Multisession tDCS targeting the left dorsolateral prefrontal cortex and M1 did not improve laboratory-based FOG-provoking test performance. Improvements observed in participants with mild-to-moderate FOG severity warrant further investigation. © 2021 International Parkinson and Movement Disorder Society.
- Subjects :
- medicine.medical_specialty
Parkinson's disease
genetic structures
medicine.medical_treatment
Prefrontal Cortex
Stimulation
Transcranial Direct Current Stimulation
law.invention
Physical medicine and rehabilitation
Double-Blind Method
Randomized controlled trial
law
Humans
Daily living
Medicine
Gait
Gait Disorders, Neurologic
Transcranial direct-current stimulation
business.industry
Motor Cortex
Parkinson Disease
medicine.disease
Neurology
Test performance
Neurology (clinical)
Primary motor cortex
business
Subjects
Details
- ISSN :
- 15318257 and 08853185
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Movement Disorders
- Accession number :
- edsair.doi.dedup.....204100775611fa9227e8f55f98f2bc2a