Back to Search
Start Over
Small interfering RNA for cancer treatment: overcoming hurdles in delivery
- Source :
- Acta Pharmaceutica Sinica. B
- Publication Year :
- 2020
-
Abstract
- In many ways, cancer cells are different from healthy cells. A lot of tactical nano-based drug delivery systems are based on the difference between cancer and healthy cells. Currently, nanotechnology-based delivery systems are the most promising tool to deliver DNA-based products to cancer cells. This review aims to highlight the latest development in the lipids and polymeric nanocarrier for siRNA delivery to the cancer cells. It also provides the necessary information about siRNA development and its mechanism of action. Overall, this review gives us a clear picture of lipid and polymer-based drug delivery systems, which in the future could form the base to translate the basic siRNA biology into siRNA-based cancer therapies.<br />Graphical abstract The latest development in the lipids and polymeric nanocarrier for siRNA delivery to the cancer cells were highlighted. It also provides the necessary information about siRNA development and its mechanism of action.Image 1
- Subjects :
- Small interfering RNA
PE-PCL-b-PNVCL, pentaerythritol polycaprolactone-block-poly(N-vinylcaprolactam)
DSPE-MPEG, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)
Review
0302 clinical medicine
micro RNA, MPEG
poly(ethylene glycol)-block-poly(l-lysine), PEI
General Pharmacology, Toxicology and Pharmaceutics
Polymer
Micelles
Cancer
DOPC, dioleylphosphatidyl choline
DSPE-PEG-Mal: 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000] (mmmonium salt), EPR
0303 health sciences
poly(acrylhydrazine)-block-poly(3-dimethylaminopropyl methacrylamide)-block-poly(acrylhydrazine), PCL
S–Au, thio‒gold
AQP-5, aquaporin-5
CMC, critical micelles concentration
DOTAP, N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methyl-sulfate
Cancer treatment
APOB, apolipoprotein B
Nanomedicine
RNAi, RNA interference
poly(ethylene glycol)-block-poly(2-dimethylaminoethyl methacrylate)-block poly(pyrenylmethyl methacrylate), PEG-b-PLL
030220 oncology & carcinogenesis
B-PEI, branched polyethlenimine
Atufect01, β-l-arginyl-2,3-l-diaminopropionicacid-N-palmityl-N-oleyl-amide trihydrochloride
CHEMS, cholesteryl hemisuccinate
DSGLA, N,N-dis-tearyl-N-methyl-N-2[N′-(N2-guanidino-l-lysinyl)] aminoethylammonium chloride
SEM, scanning electron microscope
messenger RNA, MTX
polycaprolactone-polyethylenimine, PDMA
BMA, butyl methacrylate
03 medical and health sciences
TCC - Transitional cell carcinoma
RNAse III, ribonuclease III enzyme
methotrexate, NIR
ZEBOV, Zaire ebola virus
DSPC, 1,2-distearoyl-sn-glycero-3-phosphocholine
lysine ethyl ester diisocyanate, LPD/LPH
poly(N-isopropyl acrylamide), pentaerythritol polycaprolactone-block-poly(N-isopropylacrylamide)
medicine.disease
CFTR, cystic fibrosis transmembrane conductance regulator gene
UV, ultraviolet
Cancer cell
Liposomes
PPES-b-PEO-b-PPES, poly(4-(phenylethynyl)styrene)-block-PEO-block-poly(4-(phenylethynyl)styrene)
RES, reticuloendothelial system
hypoxia-inducible factor-1α, KSP
DMAEMA, 2-dimethylaminoethyl methacrylate
N-acetylgalactosamine, HIF-1α
DNA, deoxyribonucleic acid
USPIO, ultra-small superparamagnetic iron oxide nanoparticles
enhanced permeability and retention, Galnac
RISC, RNA-induced silencing complex
nanoparticle, NRP-1
near-infrared, NP
methoxypoly(ethylene glycol), MPEG-PCL
1,3-propanediol, PEG-b-PDMAEMA-b-Ppy
neuropilin-1, PAA
PLGA, poly lactic-co-glycolic acid
methoxy polyethylene glycol-polycaprolactone, mRNA
poly(N,N-dimethylacrylamide), PDO
VEGF, vascular endothelial growth factor
PLL, poly-l-lysine
lipid-protamine-DNA/hyaluronic acid, MDR
DSPE, 1,2-distearoyl-sn-glycero-3-phosphorylethanolamine
Drug delivery
RGD, Arg-Gly-Asp peptide
SNALP, stable nucleic acid-lipid particles
poly(Ε-caprolactone)-polyethyleneglycol-poly(l-histidine), PCL-PEI
DOTMA, N-[1-(2,3-dioleyloxy)propy]-N,N,N-trimethylammoniumchloride
kinesin spindle protein, LDI
Small interfering RNA (siRNA)
2-propylacrylicacid, PAH-b-PDMAPMA-b-PAH
AZEMA, azidoethyl methacrylate
poly(ethylene oxide)-block-poly(2-(diethylamino)ethyl methacrylate)-stat-poly(methoxyethyl methacrylate), PEO-b-PCL
AuNPs, gold nanoparticles
TCC, transitional cell carcinoma
Tf, transferrin
medicine
multiple drug resistance, MiRNA
TEM, transmission electron microscopy
030304 developmental biology
PLK-1, polo-like kinase 1
poly(ethylene oxide)-block-poly(Ε-caprolactone), PE-PCL-b-PNIPAM
poly(Ε-caprolactone), PCL-PEG
CHOL, cholesterol
PLA, poly-l-arginine
DC-Chol, 3β-[N-(N′,N′-dimethylaminoethane)carbamoyl]cholesterol
Trka, tropomyosin receptor kinase A
polyethylenimine, PEO-b-P(DEA-Stat-MEMA
DOX, doxorubicin
polycaprolactone-polyethyleneglycol, PCL-PEG-PHIS
DOPE, dioleylphosphatidyl ethanolamine
PTX, paclitaxel
PiRNA, piwi-interacting RNA
Cancer research
RNA, ribonucleic acid
SiRNA, short interfering rNA
Nanocarriers
Subjects
Details
- ISSN :
- 22113835
- Volume :
- 10
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Acta pharmaceutica Sinica. B
- Accession number :
- edsair.doi.dedup.....2071f422f1c1f8a688b18780d3afbc9c