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Association between the tissue accumulation of advanced glycation end products and exercise capacity in cardiac rehabilitation patients
- Source :
- BMC Cardiovascular Disorders, 20(1):195. BioMed Central Ltd., BMC Cardiovascular Disorders, Vol 20, Iss 1, Pp 1-9 (2020), BMC Cardiovascular Disorders
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Background Advanced glycation end products (AGEs) are associated with aging, diabetes mellitus (DM), and other chronic diseases. Recently, the accumulation of AGEs can be evaluated by skin autofluorescence (SAF). However, the relationship between SAF levels and exercise capacity in patients with cardiovascular disease (CVD) remains unclear. This study aimed to investigate the association between the tissue accumulation of AGEs and clinical characteristics, including exercise capacity, in patients with CVD. Methods We enrolled 319 consecutive CVD patients aged ≥40 years who underwent early phase II cardiac rehabilitation (CR) at our university hospital between November 2015 and September 2017. Patient background, clinical data, and the accumulation of AGEs assessed by SAF were recorded at the beginning of CR. Characteristics were compared between two patient groups divided according to the median SAF level (High SAF and Low SAF). Results The High SAF group was significantly older and exhibited a higher prevalence of DM than the Low SAF group. The sex ratio did not differ between the two groups. AGE levels showed significant negative correlations with peak oxygen uptake and ventilator efficiency (both P P P = 0.02). Conclusion High levels of tissue accumulated AGEs, as assessed by SAF, were significantly and independently associated with reduced exercise capacity. These data suggest that measuring the tissue accumulation of AGEs may be useful in patients who have undergone CR, irrespective of whether they have DM.
- Subjects :
- Glycation End Products, Advanced
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
Cardiac rehabilitation
030204 cardiovascular system & hematology
Logistic regression
Gastroenterology
MUSCLE STRENGTH
0302 clinical medicine
Glycation
Advanced glycation end products
PREDICTORS
Skin
VO2 max
Middle Aged
Cardiac surgery
Treatment Outcome
Cardiovascular Diseases
HEART-FAILURE
Female
Cardiology and Cardiovascular Medicine
Research Article
Adult
medicine.medical_specialty
030209 endocrinology & metabolism
03 medical and health sciences
Exercise tolerance
Internal medicine
Diabetes mellitus
medicine
Humans
TOLERANCE
Aged
Retrospective Studies
Angiology
business.industry
MORTALITY
fungi
SKIN AUTOFLUORESCENCE
Odds ratio
medicine.disease
Confidence interval
DIABETIC-PATIENTS
OXYGEN-CONSUMPTION
RISK PATIENTS
Cross-Sectional Studies
lcsh:RC666-701
MARKER
business
Biomarkers
Subjects
Details
- ISSN :
- 14712261
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- BMC Cardiovascular Disorders
- Accession number :
- edsair.doi.dedup.....207ec5b8f1c50fdce69dc6d4b1719fec
- Full Text :
- https://doi.org/10.1186/s12872-020-01484-3