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Management and prognosis of 66 patients with B-cell non-Hodgkin lymphoma presenting with initial spinal cord compression: a French retrospective multicenter study
- Source :
- Leukemia & lymphoma, Leukemia & lymphoma, 2015, 56 (7), pp.2025-31
- Publication Year :
- 2014
-
Abstract
- International audience; Initial spinal cord compression (ISCC) in B-cell non-Hodgkin lymphoma (NHL) is rarely present at diagnosis. We performed a multicenter retrospective analysis of 66 patients with ISCC, including diffuse large B-cell (DLBCL) (70%), follicular (20%), small lymphocytic (6%), marginal zone (2%) and B-cell unclassified (2%) lymphomas, with the aim of describing their management and outcomes, as well as the occurrence of central nervous system (CNS) relapses. All but two patients received cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) or CHOP-like regimens, with rituximab in 61% of cases. Forty-six patients received CNS prophylaxis. The 5-year overall survival and progression-free survival were 78% and 65% for DLBCL, and 60% and 48% for indolent lymphomas, respectively. CNS relapses occurred in four (6%) patients, all with DLBCL and all in the cerebellum. Initial decompressive procedures, intradural involvement, cerebrospinal fluid infiltration and lack of CNS prophylaxis did not influence survival. Adverse prognostic factors were male sex, poor performance status, elevated lactate dehydrogenase and high age-adjusted international prognostic index.
- Subjects :
- Male
Cancer Research
CHOP
Gastroenterology
Central Nervous System Neoplasms
International Prognostic Index
Prednisone
immune system diseases
hemic and lymphatic diseases
Antineoplastic Combined Chemotherapy Protocols
Medicine
Aged, 80 and over
B-Lymphocytes
Lymphoma, Non-Hodgkin
Disease Management
Hematology
Middle Aged
Prognosis
Combined Modality Therapy
Survival Rate
Oncology
Vincristine
B-Cell Non-Hodgkin Lymphoma
Rituximab
Female
management
medicine.drug
central nervous system relapse
Adult
medicine.medical_specialty
lymphoma
[SDV.CAN]Life Sciences [q-bio]/Cancer
Young Adult
Spinal cord compression
Internal medicine
Humans
Cyclophosphamide
Aged
Neoplasm Staging
Retrospective Studies
business.industry
medicine.disease
Surgery
Lymphoma
Doxorubicin
Cranial Irradiation
Neoplasm Recurrence, Local
business
Spinal Cord Compression
Follow-Up Studies
Subjects
Details
- ISSN :
- 10292403
- Volume :
- 56
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Leukemialymphoma
- Accession number :
- edsair.doi.dedup.....2080df416c1768deeeb58bf7da61222f