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JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila
- Source :
- ResearcherID
- Publication Year :
- 2003
-
Abstract
- Changes in the genetic makeup of an organism can extend lifespan significantly if they promote tolerance to environmental insults and thus prevent the general deterioration of cellular function that is associated with aging. Here, we introduce the Jun N-terminal kinase (JNK) signaling pathway as a genetic determinant of aging in Drosophila melanogaster. Based on expression profiling experiments, we demonstrate that JNK functions at the center of a signal transduction network that coordinates the induction of protective genes in response to oxidative challenge. JNK signaling activity thus alleviates the toxic effects of reactive oxygen species (ROS). In addition, we show that flies with mutations that augment JNK signaling accumulate less oxidative damage and live dramatically longer than wild-type flies. Our work thus identifies the evolutionarily conserved JNK signaling pathway as a major genetic factor in the control of longevity.
- Subjects :
- Aging
Transgene
Oxidative phosphorylation
Biology
medicine.disease_cause
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Life Expectancy
medicine
Phosphoprotein Phosphatases
Animals
Drosophila Proteins
Transgenes
Molecular Biology
030304 developmental biology
Regulation of gene expression
chemistry.chemical_classification
Genetics
0303 health sciences
Reactive oxygen species
JNK Mitogen-Activated Protein Kinases
Cell Biology
biology.organism_classification
Phenotype
Cell biology
Oxidative Stress
Drosophila melanogaster
chemistry
Gene Expression Regulation
Signal transduction
Mitogen-Activated Protein Kinases
Reactive Oxygen Species
030217 neurology & neurosurgery
Oxidative stress
Developmental Biology
Signal Transduction
Subjects
Details
- ISSN :
- 15345807
- Volume :
- 5
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Developmental cell
- Accession number :
- edsair.doi.dedup.....20813a8aa6d7e3716821b0de8b9f0f84