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Efficacy of prophylactic irradiation to the contralateral testis for patients with advanced-stage primary testicular lymphoma: an analysis of outcomes at a single institution
Efficacy of prophylactic irradiation to the contralateral testis for patients with advanced-stage primary testicular lymphoma: an analysis of outcomes at a single institution
- Source :
- International Journal of Hematology. 106:533-540
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Primary testicular lymphoma (PTL) is a rare, extranodal lymphoma that often relapses in the contralateral testis. We evaluated outcomes in patients with any stage of PTL who had received CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone) with rituximab chemotherapy and prophylactic radiotherapy to the contralateral testis. We retrospectively identified 15 patients (median age 66 years; range 39–81) diagnosed with diffuse large B-cell PTL in the period 2000–2014. Characteristics and outcomes of these cases were evaluated. All patients received initial orchiectomy followed by CHOP with or without rituximab. Thirteen patients received prophylactic irradiation to the contralateral testis. During follow-up (median 67 months; range 8–190), one patient died of PTL, three died of other disease, and nine were free from relapse. For stage I–II disease, 5-year progression-free and overall survival rates were 80 and 100%, respectively. For stage III–IV PTL, 5-year progression-free and overall survival rates were 50 and 72%, respectively. Notably, no patient developed contralateral testicular involvement after prophylactic irradiation. The observed outcomes suggest that the combination of (i) CHOP plus rituximab and (ii) radiotherapy for local recurrence prophylaxis is promising for both stage I–II and stage III–IV PTL.
- Subjects :
- Adult
Male
Vincristine
medicine.medical_specialty
Lymphoma
Cyclophosphamide
medicine.medical_treatment
CHOP
Disease-Free Survival
Antibodies, Monoclonal, Murine-Derived
03 medical and health sciences
0302 clinical medicine
Testicular Neoplasms
hemic and lymphatic diseases
Antineoplastic Combined Chemotherapy Protocols
Testis
Humans
Medicine
Stage (cooking)
Aged
Retrospective Studies
Aged, 80 and over
Chemotherapy
Radiotherapy
business.industry
Hematology
Middle Aged
Surgery
Survival Rate
Doxorubicin
030220 oncology & carcinogenesis
embryonic structures
Prednisolone
Prednisone
Testicular Involvement
Rituximab
business
Follow-Up Studies
030215 immunology
medicine.drug
Subjects
Details
- ISSN :
- 18653774 and 09255710
- Volume :
- 106
- Database :
- OpenAIRE
- Journal :
- International Journal of Hematology
- Accession number :
- edsair.doi.dedup.....209241a985731cf4fc252665ee57acfc
- Full Text :
- https://doi.org/10.1007/s12185-017-2274-5