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In vitro antibacterial activity of cefiderocol against recent multidrug-resistant carbapenem-nonsusceptible Enterobacterales isolates

In vitro antibacterial activity of cefiderocol against recent multidrug-resistant carbapenem-nonsusceptible Enterobacterales isolates

Authors :
Qingyu Zhang
Nicholas Neidig
Ting-Yu Chu
Cameron Divoky
Jessica Carpenter
Cristian Lee-Hsiao
Hillary Threatt
Rasheda Sultana
Karen Bush
Source :
Diagnostic Microbiology and Infectious Disease. 103:115651
Publication Year :
2022
Publisher :
Elsevier BV, 2022.

Abstract

Cefiderocol, a siderophore-containing cephalosporin with broad-spectrum antimicrobial activity against many β-lactam-resistant Gram-negative bacteria, was tested by broth microdilution against 104 carbapenem-non-susceptible Enterobacterales clinical isolates from 2011 to 2018. Carbapenemase identification was determined using PCR followed by targeted gene sequencing or whole genome sequencing (WGS). All isolates were multidrug-resistant, 89.4% (93/104) and produced a serine (KPC or SME) carbapenemase, with as many as four β-lactamases present. A VIM-1 or NDM-1 metallo-β-lactamase was confirmed in 6.7% of the isolates (N = 5 and 2, respectively). All isolates were susceptible to cefiderocol, unlike the comparator agents. Susceptibility for comparators ranged from 24.0% for meropenem to 91.3%, 92.3% and 96.1% for imipenem-relebactam, ceftazidime-avibactam and meropenem-vaborbactam, respectively; 48.1%, 75.2% and 79.8% of the isolates were susceptible to omadacycline, colistin and eravacycline, respectively. Two isolates with cefiderocol MICs of 2 mg/L had mutations or deletions of the iron transport genes fhuA/E or fepA, as determined by WGS.

Details

ISSN :
07328893
Volume :
103
Database :
OpenAIRE
Journal :
Diagnostic Microbiology and Infectious Disease
Accession number :
edsair.doi.dedup.....20c59b10b71087ca590a977c9208195a
Full Text :
https://doi.org/10.1016/j.diagmicrobio.2022.115651