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Growth differentiation factor–15 predicts the prognoses of patients with acute coronary syndrome: a meta-analysis
- Source :
- BMC Cardiovascular Disorders
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Background Recent studies have shown Growth differentiation factor–15 (GDF-15) that is a member of the transforming growth factor β (TGF-β) superfamily might be a potential predictive cytokine for the prognosis of Acute coronary syndrome (ACS). However, there are discrepancies in these studies. Methods Publication searches of the PubMed/Medline and EMBASE databases were performed without any time or ethnicity restrictions. The inclusion and exclusion criteria, when clear, were addressed. Random effects models were used for all analyses. Publication bias was tested using funnel plots and the Egger test. Results We identified eight eligible studies that provided mortality data. Five of these studies provided recurrent myocardial infarction (MI) data. The maximal duration of follow-up ranged from 6 months to 6 years. A significant association was found between the patients with the highest and lowest GDF-15 levels (overall analyses) in terms of mortality (p
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Funnel plot
Acute coronary syndrome
Growth Differentiation Factor 15
Time Factors
Myocardial Infarction
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Recurrence
Risk Factors
Internal medicine
Odds Ratio
medicine
Humans
Acute Coronary Syndrome
business.industry
Hazard ratio
Odds ratio
Publication bias
Prognosis
medicine.disease
Up-Regulation
030104 developmental biology
Meta-analysis
Predictive value of tests
GDF15
Cardiology and Cardiovascular Medicine
business
Biomarkers
Research Article
Subjects
Details
- ISSN :
- 14712261
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- BMC Cardiovascular Disorders
- Accession number :
- edsair.doi.dedup.....20da4781f6d2df4f0cd05547ce995719