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Tumour necrosis factor-related apoptosis-inducing ligand expression in patients with diabetic nephropathy
- Source :
- Journal of the Renin-Angiotensin-Aldosterone System: JRAAS, Journal of the Renin-Angiotensin-Aldosterone System, Vol 19 (2018)
- Publication Year :
- 2018
- Publisher :
- Hindawi Limited, 2018.
-
Abstract
- Objective: The objective of this study was to evaluate the expression profile of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) in patients with diabetic nephropathy (DN). Methods: A total of 126 Chinese subjects were enrolled in this study, including 42 patients with diabetes mellitus (DM), 42 patients with DN and 42 healthy controls. Real-time polymerase chain reaction was performed to analyze levels of TRAIL mRNA in peripheral blood mononuclear cells (PBMCs). Serum levels of soluble TRAIL (sTRAIL) and various cytokines were detected with a commercially available enzyme-linked immunosorbent assay kit. Results: Compared with the control group, the levels of TRAIL mRNA in PBMCs and sTRAIL in sera were both significantly decreased in the DM and DN patients ( P < 0.05). Conversely, levels of interleukin (IL)-1, IL-6, tumour necrosis factor-α and monocyte chemotactic protein-1 were higher in the DN group than in the control group. Serum levels of TRAIL positively correlated with TRAIL mRNA levels in all of the subjects examined ( P < 0.05). Conclusions: These results provide support and a theoretical basis for further research of TRAIL in regard to the pathogenesis of DN.
- Subjects :
- Male
0301 basic medicine
Medicine (General)
medicine.medical_specialty
Necrosis
TRAIL
030209 endocrinology & metabolism
Diabetic nephropathy
TNF-Related Apoptosis-Inducing Ligand
03 medical and health sciences
R5-920
0302 clinical medicine
Endocrinology
Internal medicine
Internal Medicine
Humans
Medicine
Diabetic Nephropathies
In patient
RNA, Messenger
Interleukin 6
IL-6
biology
IL-1
business.industry
Middle Aged
Ligand (biochemistry)
medicine.disease
Logistic Models
030104 developmental biology
Solubility
Apoptosis
TNF-α
Cancer research
biology.protein
Cytokines
Female
Original Article
medicine.symptom
business
Subjects
Details
- ISSN :
- 17528976 and 14703203
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Journal of the Renin-Angiotensin-Aldosterone System
- Accession number :
- edsair.doi.dedup.....20f80e5a29303e4851cf07dae8309221