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Pd-Catalyzed Transfer of Difluorocarbene
- Source :
- Organic letters. 18(17)
- Publication Year :
- 2016
-
Abstract
- The study of transition-metal difluorocarbene complex has long been a subject of active investigation, but the transition-metal-catalyzed transfer of difluorocarbene remains a significant challenge. The Pd-catalyzed transfer of difluorocarbene is described to realize the coupling reaction of boronic acids with difluorocarbene to give (difluoromethyl)arenes and -olefins. Mechanistic investigations reveal that the Pd═CF2 complex is an important intermediate for this transformation. This complex is prone to trimerization without the presence of starting materials.
Details
- ISSN :
- 15237052
- Volume :
- 18
- Issue :
- 17
- Database :
- OpenAIRE
- Journal :
- Organic letters
- Accession number :
- edsair.doi.dedup.....210099cca59e793a2c689037baab48de