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Use of hydroxychloroquine in hospitalised COVID-19 patients is associated with reduced mortality: Findings from the observational multicentre Italian CORIST study
- Source :
- European Journal of Internal Medicine
- Publication Year :
- 2020
-
Abstract
- Background Hydroxychloroquine (HCQ) was proposed as potential treatment for COVID-19. Objective We set-up a multicenter Italian collaboration to investigate the relationship between HCQ therapy and COVID-19 in-hospital mortality. Methods In a retrospective observational study, 3,451 unselected patients hospitalized in 33 clinical centers in Italy, from February 19, 2020 to May 23, 2020, with laboratory-confirmed SARS-CoV-2 infection, were analyzed. The primary end-point in a time-to event analysis was in-hospital death, comparing patients who received HCQ with patients who did not. We used multivariable Cox proportional-hazards regression models with inverse probability for treatment weighting by propensity scores, with the addition of subgroup analyses. Results Out of 3,451 COVID-19 patients, 76.3% received HCQ. Death rates (per 1,000 person-days) for patients receiving or not HCQ were 8.9 and 15.7, respectively. After adjustment for propensity scores, we found 30% lower risk of death in patients receiving HCQ (HR=0.70; 95%CI: 0.59 to 0.84; E-value=1.67). Secondary analyses yielded similar results. The inverse association of HCQ with inpatient mortality was particularly evident in patients having elevated C-reactive protein at entry. Conclusions HCQ use was associated with a 30% lower risk of death in COVID-19 hospitalized patients. Within the limits of an observational study and awaiting results from randomized controlled trials, these data do not discourage the use of HCQ in inpatients with COVID-19.
- Subjects :
- Male
medicine.medical_specialty
030204 cardiovascular system & hematology
Lower risk
law.invention
COVID-19
Disease severity
Hydroxychloroquine
Inflammation
Mortality
Aged
Aged, 80 and over
Female
Hospital Mortality
Humans
Italy
Middle Aged
Retrospective Studies
Treatment Outcome
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
Retrospective Studie
law
Internal medicine
80 and over
Internal Medicine
medicine
030212 general & internal medicine
Risk factor
business.industry
Mortality rate
Retrospective cohort study
COVID-19 Drug Treatment
Propensity score matching
Commentary
Observational study
business
Human
medicine.drug
Subjects
Details
- ISSN :
- 18790828
- Volume :
- 82
- Database :
- OpenAIRE
- Journal :
- European journal of internal medicine
- Accession number :
- edsair.doi.dedup.....21163a9931a4dc3e91b8e3feebeb7711