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Expression and function of Slc34 sodium–phosphate co-transporters in skeleton and teeth

Expression and function of Slc34 sodium–phosphate co-transporters in skeleton and teeth

Authors :
Laurent Beck
Jehan, Frederic
Université de Nantes - UFR Odontologie
Université de Nantes (UN)
Regenerative Medicine and Skeleton (RMeS)
Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE)
Université de Nantes (UN)-Université de Nantes (UN)-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)
Source :
Pflügers Archiv European Journal of Physiology, Pflügers Archiv European Journal of Physiology, Springer Verlag, 2018, Epub ahead of print. ⟨10.1007/s00424-018-2240-y⟩
Publication Year :
2018
Publisher :
Springer Science and Business Media LLC, 2018.

Abstract

International audience; Under normal physiological condition, the biomineralization process is limited to skeletal tissues and teeth and occurs throughout the individual's life. Biomineralization is an actively regulated process involving the progressive mineralization of the extracellular matrix secreted by osteoblasts in bone or odontoblasts and ameloblasts in tooth. Although the detailed molecular mechanisms underlying the formation of calcium-phosphate apatite crystals are still debated, it is suggested that calcium and phosphate may need to be transported across the membrane of the mineralizing cell, suggesting a pivotal role of phosphate transporters in bone and tooth mineralization. In this context, this short review describes the current knowledge on the role of Slc34 Na+-phosphate transporters in skeletal and tooth mineralization.

Details

ISSN :
14322013 and 00316768
Volume :
471
Database :
OpenAIRE
Journal :
Pflügers Archiv - European Journal of Physiology
Accession number :
edsair.doi.dedup.....2130f7940abd37d880fdaf12e294002f
Full Text :
https://doi.org/10.1007/s00424-018-2240-y