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Expression and function of Slc34 sodium–phosphate co-transporters in skeleton and teeth
Expression and function of Slc34 sodium–phosphate co-transporters in skeleton and teeth
- Source :
- Pflügers Archiv European Journal of Physiology, Pflügers Archiv European Journal of Physiology, Springer Verlag, 2018, Epub ahead of print. ⟨10.1007/s00424-018-2240-y⟩
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- International audience; Under normal physiological condition, the biomineralization process is limited to skeletal tissues and teeth and occurs throughout the individual's life. Biomineralization is an actively regulated process involving the progressive mineralization of the extracellular matrix secreted by osteoblasts in bone or odontoblasts and ameloblasts in tooth. Although the detailed molecular mechanisms underlying the formation of calcium-phosphate apatite crystals are still debated, it is suggested that calcium and phosphate may need to be transported across the membrane of the mineralizing cell, suggesting a pivotal role of phosphate transporters in bone and tooth mineralization. In this context, this short review describes the current knowledge on the role of Slc34 Na+-phosphate transporters in skeletal and tooth mineralization.
- Subjects :
- Biomineralization
0301 basic medicine
Physiology
Clinical Biochemistry
chemistry.chemical_element
Calcium
Mineralization (biology)
Bone and Bones
Extracellular matrix
03 medical and health sciences
chemistry.chemical_compound
Sodium-Phosphate Cotransporter Proteins, Type II
0302 clinical medicine
stomatognathic system
Physiology (medical)
Animals
Humans
Bone
Matrix vesicles
[SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system
[SDV.MHEP.GEG] Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology
Chemistry
[SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology
Transporter
Phosphate
NaPi-II
Cell biology
stomatognathic diseases
Cartilage
030104 developmental biology
Odontoblast
[SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system
Ameloblast
Tooth
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14322013 and 00316768
- Volume :
- 471
- Database :
- OpenAIRE
- Journal :
- Pflügers Archiv - European Journal of Physiology
- Accession number :
- edsair.doi.dedup.....2130f7940abd37d880fdaf12e294002f
- Full Text :
- https://doi.org/10.1007/s00424-018-2240-y