Molecular Cloning of Rat Bone Morphogenetic Protein (BMP) Type IA Receptor and Its Expression During Ectopic Bone Formation Induced by BMP

Authors :: Hidenori Ichijo
Tadahiro Iimura
Satoshi Sasaki
Shinichiro Oida
Kohsuke Takeda
Yutaka Maruoka
Teruo Amagasa
Source :: Biochemical and Biophysical Research Communications. 204:203-209
Publication Year :: 1994
Publisher :: Elsevier BV, 1994.
Abstract: A cDNA for the rat bone morphogenetic protein (BMP) type IA receptor (BMPR-IA) was isolated from a dental pulp cell cDNA library. The rat BMPR-IA cDNA encodes a protein of 532 amino acids with a single transmembrane domain and a putative serine/threonine kinase domain. The overall amino acid sequence identity between the rat and human BMPR-IA was 97 %. Reverse transcriptase-polymerase chain reaction analysis revealed that BMPR-IA mRNA was highly expressed in the BMP-induced bone forming tissues throughout the stages tested.

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