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Fatty liver and cerebrovascular disease: plausible association and possible mechanisms
- Source :
- Curr Opin Lipidol
- Publication Year :
- 2021
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2021.
-
Abstract
- Purpose of review Nonalcoholic fatty liver disease (NAFLD) is a common comorbidity and has wide ranging extrahepatic manifestations, including through cardiometabolic pathways. As such, there is growing interest in the impact of NAFLD on cerebrovascular disease and brain health more broadly. In this review, we assess recent research into understanding the association between NAFLD and brain health while highlighting potential clinical implications. Recent findings Mechanistically, NAFLD is characterized by both a proinflammatory and proatherogenic state, which results in vascular inflammation and neurodegeneration, potentially leading to clinical and subclinical cerebrovascular disease. Mounting epidemiological evidence suggests an association between NAFLD and an increased risk and severity of stroke, independent of other vascular risk factors. Studies also implicate NAFLD in subclinical cerebrovascular disease, such as carotid atherosclerosis and microvascular disease. In contrast, there does not appear to be an independent association between NAFLD and cognitive impairment. Summary The current literature supports the formulation of NAFLD as a multisystem disease that may also have implications for cerebrovascular disease and brain health. Further prospective studies are needed to better assess a temporal relationship between the two diseases, confirm these early findings, and decipher mechanistic links.
- Subjects :
- Carotid Artery Diseases
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Disease
Bioinformatics
digestive system
Article
Non-alcoholic Fatty Liver Disease
Risk Factors
Epidemiology
Nonalcoholic fatty liver disease
Genetics
medicine
Humans
Prospective cohort study
Molecular Biology
Stroke
Subclinical infection
Nutrition and Dietetics
business.industry
Fatty liver
Brain
nutritional and metabolic diseases
Cell Biology
medicine.disease
Comorbidity
digestive system diseases
Cerebrovascular Disorders
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 14736535 and 09579672
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Lipidology
- Accession number :
- edsair.doi.dedup.....214a1082c74c071e84cc8df73479dd1c