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Adult pertussis vaccination strategies and their impact on pertussis in the United States: evaluation of routine and targeted (cocoon) strategies
- Source :
- Epidemiology and Infection. 136:604-620
- Publication Year :
- 2007
- Publisher :
- Cambridge University Press (CUP), 2007.
-
Abstract
- SUMMARYA compartmental, age-structured mathematical model was developed and recent US pertussis epidemiology data were used to evaluate the impact on pertussis infection rates of routine and targeted adult immunization strategies. Model simulations predict that the implementation of adolescent immunization only could reverse the current rise in pertussis infection rates but may lead to a resurgence of pertussis in subsequent decades. In contrast, inclusion of a routine adult strategy is likely to lead to sustained control of pertussis. Routine adult vaccination could control the disease even with relatively low coverage rates of 40% for routine vaccination of all adults every 10 years, or 65% for a targeted vaccination of close contacts of newborns completed by one booster dose for all adults. The model also predicts that the optimal age for this booster dose is 40 years. These results support the 2006 American Academy of Immunization Practices' recommendations for adolescent and adult vaccination against pertussis.
- Subjects :
- Adult
Adult Immunization
Pediatrics
medicine.medical_specialty
Whooping Cough
Epidemiology
Booster dose
Disease
Humans
Medicine
Pertussis vaccination
Routine vaccination
Child
Immunization Schedule
Pertussis Vaccine
Immunization Programs
business.industry
Incidence
Infant, Newborn
Infant
Models, Theoretical
Original Papers
United States
Vaccination
Infectious Diseases
Immunization
Child, Preschool
Immunology
business
Subjects
Details
- ISSN :
- 14694409 and 09502688
- Volume :
- 136
- Database :
- OpenAIRE
- Journal :
- Epidemiology and Infection
- Accession number :
- edsair.doi.dedup.....2152050e4231a99b5e6e3036f0533b18