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Pros and cons of mouse models for studying osteoarthritis
- Source :
- Clinical and Translational Medicine, Clinical and Translational Medicine, Vol 7, Iss 1, Pp 1-13 (2018)
- Publication Year :
- 2018
-
Abstract
- Osteoarthritis (OA) is one of the most common chronic conditions in the world today. It results in breakdown of cartilage in joints and causes the patient to experience intense pain and even disability. The pathophysiology of OA is not fully understood; therefore, there is currently no cure for OA. Many researchers are investigating the pathophysiology of the disease and attempting to develop methods to alleviate the symptoms or cure the OA entirely using animal models. Most studies on OA use animal models; this is necessary as the disease develops very slowly in humans and presents differently in each patient. This makes it difficult to effectively study the progression of osteoarthritis. Animal models can be spontaneous, in which OA naturally occurs in the animal. Genetic modifications can be used to make the mice more susceptible to developing OA. Osteoarthritis can also be induced via surgery, chemical injections, or non-invasive trauma. This review aims to describe animal models of inducing osteoarthritis with a focus on the models used on mice and their advantages and disadvantages that each model presents.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Mouse
Medicine (miscellaneous)
Disease
Osteoarthritis
Review
Horse
03 medical and health sciences
0302 clinical medicine
Chemically induced
Surgical
medicine
Non-invasive
Intensive care medicine
030203 arthritis & rheumatology
lcsh:R5-920
business.industry
Non invasive
medicine.disease
Guinea pig
Animal models
030104 developmental biology
Medicine public health
Molecular Medicine
business
lcsh:Medicine (General)
Subjects
Details
- ISSN :
- 20011326
- Volume :
- 7
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Clinical and translational medicine
- Accession number :
- edsair.doi.dedup.....2159050f1802cd65a2b96e0c05ca88a0