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Free Fatty Acid is a Promising Biomarker in Triage Screening for Patients with Colorectal Cancer: A Case–Control Study
- Source :
- Cancer Management and Research
- Publication Year :
- 2021
- Publisher :
- Informa UK Limited, 2021.
-
Abstract
- Bin Zhu,1 Junrong Zhang,2 Qingzhu Zheng,1 Binhua Dong,3 Meihua Wang,1 Jin Liu,1 Yingping Cao1 1Department of Clinical Laboratory, Fujian Medical University Union Hospital, Fuzhou, 350001, People’s Republic of China; 2Department of Emergency Surgery, Fujian Medical University Union Hospital, Fuzhou, 350001, People’s Republic of China; 3Laboratory of Gynecologic Oncology, Fujian Provincial Maternity and Children’s Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, 350001, People’s Republic of ChinaCorrespondence: Yingping CaoDepartment of Clinical Laboratory, Fujian Medical University Union Hospital, No. 29, Xinquan Road, Fuzhou City, Fujian Province, People’s Republic of ChinaEmail caoyingping918@sina.comPurpose: The aim of our study was to identify the diagnostic ability of free fatty acids (FFAs) in younger colorectal cancer (CRC) patients by comparing carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9).Methods: Patients screened for CRC at Fujian Medical University Union Hospital from January 2011 to December 2014 were recruited. Patients pathologically diagnosed with CRC or colorectal adenoma (CA) and healthy control participants were included. The enzyme endpoint method was applied to measure FFA levels. Receiver operating characteristic (ROC) curve analysis was performed to further evaluate the diagnostic ability of FFAs.Results: FFA levels in late-stage patients (tumour-node-metastasis (TNM) stages III–IV) were higher than those in early-stage patients (TNM stages I–II) (P=0.02). The FFA levels in CRC patients were higher than those in controls of all ages, those younger than 50 years, males and females (P< 0.001), and this difference was larger for patients younger than 50 years and females than for the all ages group. There was no significant difference in the FFA level between CA patients and healthy participants (P=0.53). The area under the curve (AUC) values of FFA, CEA, CA19-9, FFA+CEA, FFA+CA19-9 and FFA+CEA+CA19-9 distinguished CRC patients from controls at all ages, with values of 0.604, 0.731, 0.640, 0.754, 0.678 and 0.758, respectively; however, in the younger CRC patients (age≤ 50), the AUC values were 0.701, 0.735, 0.669, 0.798, 0.749, and 0.801. The AUC in female patients younger than 50 years was larger than that in males (0.769 vs 0.660), and this value was greater than the value for CEA in males (0.739) and females (0.729).Conclusion: The FFA level not only can complement the predictive ability of the CEA and CA19-9 levels but also has a superior predictive ability in female and younger patients with CRC. FFA levels may have a potential role in triage screening of early CRC.Keywords: free fatty acid, colorectal cancer, colorectal adenoma, sex, younger patients
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Colorectal cancer
colorectal cancer
Colorectal adenoma
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Carcinoembryonic antigen
Internal medicine
medicine
sex
Original Research
colorectal adenoma
chemistry.chemical_classification
biology
Receiver operating characteristic
business.industry
younger patients
Area under the curve
Case-control study
Fatty acid
medicine.disease
digestive system diseases
030104 developmental biology
Oncology
chemistry
Cancer Management and Research
030220 oncology & carcinogenesis
biology.protein
Biomarker (medicine)
business
free fatty acid
Subjects
Details
- ISSN :
- 11791322
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Cancer Management and Research
- Accession number :
- edsair.doi.dedup.....216280b4cb8bf8e55d69177d32d3e969