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Antinociceptive and anti-inflammatory effects of hydrazone derivatives and their possible mechanism of action in mice
- Source :
- PLoS ONE, PLoS ONE, Vol 16, Iss 11, p e0258094 (2021)
- Publication Year :
- 2021
- Publisher :
- Public Library of Science (PLoS), 2021.
-
Abstract
- Pain and inflammation are unpleasant experiences that usually occur as a result of tissue damage. Despite the number of existing analgesic drugs, side effects limit their use, stimulating the search for new therapeutic agents. In this sense, five hydrazone derivatives (H1, H2, H3, H4, and H5), with general structure R1R2C = NNR3R4, were synthesized with molecular modification strategies. In this paper, we describe the ability of hydrazone derivatives to attenuate nociceptive behavior and the inflammatory response in mice. Antinociceptive activity was evaluated through acetic acid-induced writhing and formalin-induced nociception tests. In both experimental models, the hydrazone with the greatest potency (H5) significantly (p < 0.05) reduced nociceptive behavior. Additionally, methods of acute and chronic inflammation induced by different chemicals (carrageenan and histamine) were performed to evaluate the anti-inflammatory effect of H5. Moreover, molecular docking analysis revealed that H5 can block the COX-2 enzyme, reducing arachidonic acid metabolism and consequently decreasing the production of prostaglandins, which are important inflammatory mediators. H5 also changes locomotor activity. In summary, H5 exhibited relevant antinociceptive and anti-inflammatory potential and acted on several targets, making it a candidate for a new multi-target oral anti-inflammatory drug.
- Subjects :
- Male
Nociception
Anti-Inflammatory Agents
Social Sciences
Pharmacology
Carrageenan
Biochemistry
Mice
chemistry.chemical_compound
Medicine and Health Sciences
Edema
Psychology
Drug Interactions
Immune Response
Analgesics
Multidisciplinary
Morphine
Organic Compounds
Drugs
Neurochemistry
Neurotransmitters
Molecular Docking Simulation
Chemistry
Physical Sciences
Medicine
Sensory Perception
medicine.symptom
Histamine
Research Article
Biogenic Amines
medicine.drug_class
Science
Immunology
Analgesic
Pain
Inflammation
Anti-inflammatory
Signs and Symptoms
Toxicity Tests
medicine
Molecular modification
Animals
Pain Management
Organic Chemistry
Hydrazones
Cognitive Psychology
Chemical Compounds
Biology and Life Sciences
Opioids
chemistry
Mechanism of action
Cognitive Science
Perception
Artemia
Clinical Medicine
Neuroscience
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....2166aa3c7c572c29f3c61223fb0ea916