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Prenatal and postnatal exposure to Bisphenol A and Asthma: a systemic review and meta-analysis
- Source :
- J Thorac Dis
- Publication Year :
- 2021
- Publisher :
- AME Publishing Company, 2021.
-
Abstract
- Background Bisphenol A (BPA) is a plasticizer with high production and ubiquitous usage in polycarbonate plastics and epoxy resins. The association between prenatal or postnatal exposure to BPA and childhood wheeze/asthma has not been well established. Our study aimed to provide further justification for the current studies. Methods Studies were searched from PubMed, Web of Science, Scopus and Embase from inception until Sep 15, 2020. Meta-analysis was performed to calculate pooled adjusted odds ratios (aOR). The methodological quality of included studies was assessed by using the Newcastle Ottawa Scale (NOS). Results Of 2,814 screened articles, 9 studies with 3,885 participants were included in the final analysis. When all studies were pooled, postnatal exposure to BPA was associated with a higher risk of childhood asthma (aOR =1.43; 95% CI: 1.28-1.59) or childhood wheeze (aOR =1.38; 95% CI: 1.18-1.62). Prenatal exposure to BPA had a small but significant increased risk of childhood asthma (aOR =1.17; 95% CI: 1.01-1.34). An increased risk of childhood wheeze was related to prenatal exposure to BPA at 16 weeks' gestation (aOR =1.29; 95% CI: 1.07-1.55), but not at 26 weeks' gestation (aOR =1.07; 95% CI: 0.88-1.29) nor at random-time gestation (aOR =1.02; 95% CI: 0.89-1.16). Conclusions Prenatal and postnatal exposure to BPA was related to an increased risk of childhood asthma. However, only postnatal and early gestational exposure (at 16 weeks) to BPA could induce the risk of childhood wheeze, but not late gestational exposure (at 26 weeks).
- Subjects :
- Pulmonary and Respiratory Medicine
Childhood asthma
medicine.medical_specialty
business.industry
Obstetrics
Odds ratio
010501 environmental sciences
medicine.disease
01 natural sciences
Newcastle–Ottawa scale
03 medical and health sciences
0302 clinical medicine
Increased risk
Wheeze
Meta-analysis
Medicine
Gestation
Original Article
030212 general & internal medicine
medicine.symptom
business
0105 earth and related environmental sciences
Asthma
Subjects
Details
- ISSN :
- 20776624 and 20721439
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Journal of Thoracic Disease
- Accession number :
- edsair.doi.dedup.....216c83344e48474d3bfbcf5813a54e84