Back to Search
Start Over
Role of liver biopsy in the era of clinical prediction scores for 'drug-induced liver injury' (DILI): experience of a tertiary referral hospital
- Source :
- Virchows Archiv. 477:517-525
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- The clinical implications of the biopsy findings in cases of drug-induced liver injury (DILI) are not fully elucidated. The aim of this study was to evaluate the histopathological findings of cases diagnosed as DILI and to correlate them with clinical and biochemical findings (such as causality assessment algorithms). We searched our department database for all cases of liver biopsy with findings consistent with toxic liver disease and selected those with a clinical diagnosis of DILI. The causative relationships were established according to Roussel Uclaf Causality Assessment Method (RUCAM). A total of 53 cases of DILI were reviewed, most of them diagnosed in hospitalized patients (83%). The analytical toxicity profile was hepatocellular (R > 5) in 60% of the cases and cholestatic (R
- Subjects :
- Adult
Male
0301 basic medicine
Drug
medicine.medical_specialty
Adolescent
Databases, Factual
Biopsy
media_common.quotation_subject
Tertiary referral hospital
Risk Assessment
Gastroenterology
Pathology and Forensic Medicine
Tertiary Care Centers
Young Adult
03 medical and health sciences
0302 clinical medicine
Cholestasis
Predictive Value of Tests
Risk Factors
Internal medicine
medicine
Humans
Referral and Consultation
Molecular Biology
Toxicity profile
Aged
Retrospective Studies
media_common
Liver injury
medicine.diagnostic_test
business.industry
Cell Biology
General Medicine
Middle Aged
medicine.disease
030104 developmental biology
Liver
030220 oncology & carcinogenesis
Liver biopsy
Assessment methods
Female
Chemical and Drug Induced Liver Injury
business
Algorithms
Subjects
Details
- ISSN :
- 14322307 and 09456317
- Volume :
- 477
- Database :
- OpenAIRE
- Journal :
- Virchows Archiv
- Accession number :
- edsair.doi.dedup.....217b4879bd4d6d4ab8a520fa74855da3