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Dopamine modulates carotid nerve responses induced by acetylcholine on the cat petrosal ganglion in vitro
- Source :
- Brain Research. 831:97-103
- Publication Year :
- 1999
- Publisher :
- Elsevier BV, 1999.
-
Abstract
- We have recently reported that application of acetylcholine (ACh) or nicotine to the petrosal ganglion-the sensory ganglion of the glossopharyngeal nerve-elicits a burst of discharges in the carotid nerve branch, innervating the carotid body and sinus, but not in the glossopharyngeal branch, innervating the tongue and pharynx. Thus, the perikarya of sensory neurons for the carotid bifurcation exhibit selective cholinosensitivity. Since dopamine (DA) modulates carotid nerve chemosensory activity, we searched for the presence of DA sensitivity at the perikarya of these neurons in the cat petrosal ganglion superfused in vitro. Applications of DA in doses of up to 5 mg to the ganglion did not modify the rate of spontaneous discharges in the carotid nerve. However, if DA was applied 30 s before ACh injections, ACh-evoked reactions were modified: low doses of DA enhanced the subsequent responses to ACh, while high doses of DA depressed the responses to ACh. This depressant effect of DA on ACh responses was partially antagonized by adding spiroperone to the superfusate. Our results show that the response to ACh of petrosal ganglion neurons projecting through the carotid nerve is modulated by DA acting on D(2) receptors located in the somata of these neurons. Thus, dopaminergic modulation of cholinosensitivity could be shared also by the membranes of peripheral endings and perikarya of primary sensory neurons involved in arterial chemoreception.
- Subjects :
- Male
medicine.medical_specialty
Chemoreceptor
Dopamine
chemistry.chemical_compound
Ganglia, Sensory
Internal medicine
Neural Pathways
medicine
Animals
Neurotransmitter
Molecular Biology
Glossopharyngeal Nerve
Neurons
General Neuroscience
Acetylcholine
Sensory neuron
Ganglion
Perfusion
Carotid Sinus
medicine.anatomical_structure
Endocrinology
nervous system
chemistry
Sensory Ganglion
Cats
Female
Carotid body
Neurology (clinical)
Neuroscience
Developmental Biology
medicine.drug
Subjects
Details
- ISSN :
- 00068993
- Volume :
- 831
- Database :
- OpenAIRE
- Journal :
- Brain Research
- Accession number :
- edsair.doi.dedup.....2189df378926b0dd5d929ae8c6f4672a