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SNP rs11185644 of RXRA gene is identified for dose-response variability to vitamin D3 supplementation: a randomized clinical trial
- Source :
- Scientific Reports
- Publication Year :
- 2017
- Publisher :
- Nature Publishing Group, 2017.
-
Abstract
- The level of serum 25-Hydroxyvitamin D [25(OH)D] has high heritability, suggesting that genes may contribute to variations in serum 25(OH)D level and vitamin D dose-response. As vitamin D deficiency has been linked to numerous diseases, understanding how genetic variation contributes to vitamin D dose-response is important for personalized vitamin D treatment and cost-effective disease prevention. To identify genetic variants responsible for vitamin D status and dose-response, we performed two vitamin D3 and calcium clinical supplementation trials in 2,207 postmenopausal Caucasian women. We examined the association of 291 SNPs with baseline serum 25(OH)D levels and 25(OH)D dose-response. Five SNPs, rs10500804 (P = 4.93 × 10−7), rs2060793 (P = 6.63 × 10−7), rs10741657 (P = 1.49 × 10−6), rs10766197 (P = 1.05 × 10−5) and rs11023380 (P = 7.67 × 10−5) in the CYP2R1 gene, as well as 6 SNPs, rs4588 (P = 7.86 × 10−7), rs2298850 (P = 1.94 × 10−6), rs1155563 (P = 6.39 × 10−6), rs705119 (P = 2.80 × 10−5), rs705120 (P = 1.08 × 10−4) and rs222040 (P = 1.59 × 10−4) in the GC gene were associated with baseline serum 25(OH)D levels. SNP rs11185644 near the RXRA was significantly associated with 25(OH)D dose-response (P = 1.01 × 10−4). Our data suggest that polymorphisms in the CYP2R1 and GC gene may contribute to variation in baseline serum 25(OH)D concentration, and that polymorphism rs11185644 may contribute to variation in 25(OH)D dose-response in healthy postmenopausal Caucasian women.
- Subjects :
- 0301 basic medicine
Vitamin
medicine.medical_specialty
030209 endocrinology & metabolism
Single-nucleotide polymorphism
Polymorphism, Single Nucleotide
Article
vitamin D deficiency
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Polymorphism (computer science)
Internal medicine
Genetic variation
medicine
Vitamin D and neurology
Humans
SNP
Vitamin D
Cholecalciferol
Retinoid X Receptor alpha
Multidisciplinary
Dose-Response Relationship, Drug
business.industry
Middle Aged
medicine.disease
3. Good health
Postmenopause
030104 developmental biology
Endocrinology
chemistry
Dietary Supplements
Female
business
Subjects
Details
- Language :
- English
- ISSN :
- 20452322 and 10500804
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....21a7bbe9d4a9c3dc763b2bc3b752a3d3
- Full Text :
- https://doi.org/10.1038/srep40593