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5-Aminosalicylic acid intolerance is associated with a risk of adverse clinical outcomes and dysbiosis in patients with ulcerative colitis
- Source :
- Intestinal Research, Intestinal Research, Vol 18, Iss 1, Pp 69-78 (2020)
- Publication Year :
- 2020
- Publisher :
- Korean Association for the Study of Intestinal Diseases, 2020.
-
Abstract
- Background/Aims: 5-Aminosalicylic acid (ASA) causes intolerance reactions in some patients. This study was performed to examine the prognosis of patients with ulcerative colitis (UC) and 5-ASA intolerance, and to evaluate the potential interaction between 5-ASA intolerance and the intestinal microbiota. Methods: We performed a retrospective cohort study of patients with UC who visited participating hospitals. The primary endpoint was to compare the incidence of hospitalization within 12 months between the 5-ASA intolerance group and the 5-ASA tolerance group. The secondary endpoint was to compare the risk of adverse clinical outcomes after the start of biologics between the 2 groups. We also assessed the correlation between 5-ASA intolerance and microbial change in an independently recruited cohort of patients with UC. Results: Of 793 patients, 59 (7.4%) were assigned to the 5-ASA intolerance group and 734 (92.5%) were assigned to the 5-ASA tolerance group. The admission rate and incidence of corticosteroid use were significantly higher in the intolerance than tolerance group (P
- Subjects :
- medicine.medical_specialty
Aminosalicylic acid
5-Aminosalicylic acid
lcsh:Medicine
Colitis, ulcerative
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Clinical endpoint
Medicine
lcsh:RC799-869
Colitis
business.industry
Incidence (epidemiology)
lcsh:R
Gastroenterology
Retrospective cohort study
Inflammatory Bowel Diseases
Prognosis
medicine.disease
Ulcerative colitis
digestive system diseases
surgical procedures, operative
chemistry
030220 oncology & carcinogenesis
Cohort
Dysbiosis
lcsh:Diseases of the digestive system. Gastroenterology
Original Article
030211 gastroenterology & hepatology
business
Subjects
Details
- ISSN :
- 22881956 and 15989100
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Intestinal Research
- Accession number :
- edsair.doi.dedup.....21d038cfd98a45ba687b75af725ef4f7