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Glucose Metabolism and Its Complicated Relationship with Tumor Growth and Perfusion in Head and Neck Squamous Cell Carcinoma
- Source :
- PLoS ONE, PLoS ONE, Vol 11, Iss 11, p e0166236 (2016)
- Publication Year :
- 2016
-
Abstract
- Objective To determine the relationship between tumor glucose metabolism and tumor blood flow (TBF) in head and neck squamous cell carcinoma (HNSCC). Methods We retrospectively analyzed 57 HNSCC patients. Tumor glucose metabolism was assessed by maximum and mean standardized uptake values (SUVmax and SUVmean) obtained by 18F-fluorodeoxyglucose positron-emission tomography. TBF values were obtained by arterial spin labeling with 3-tesla MRI. The correlations between both SUVs and TBF were assessed in the total series and among patients divided by T-stage (T1–T3 and T4 groups) and tumor location (pharynx/oral cavity and sinonasal cavity groups). Pearson’s correlation coefficients were calculated for significant correlations. Results Significant correlations were detected: a negative correlation in the advanced T-stage group (TBF and SUV max: r, −0.61, SUVmean: r, −0.62), a positive correlation in the non-advanced T-stage pharynx/oral cavity group (TBF and SUVmax: r, 0.70, SUVmean: r, 0.73), a negative correlation in the advanced T-stage pharynx/oral cavity group (TBF and SUVmax: r, −0.62, SUVmean: r, −0.65), and a negative correlation in the advanced T-stage sinonasal cavity group (TBF and SUVmax: r, −0.61, SUVmean: r, −0.65). Conclusion Significant correlations between glucose uptake and TBF in HNSCC were revealed by the division of T-stage and tumor location.
- Subjects :
- Male
Pathology
Physiology
Glucose uptake
lcsh:Medicine
Multimodal Imaging
Biochemistry
030218 nuclear medicine & medical imaging
Diagnostic Radiology
0302 clinical medicine
Glucose Metabolism
Blood Flow
Medicine and Health Sciences
lcsh:Science
Aged, 80 and over
Multidisciplinary
medicine.diagnostic_test
Organic Compounds
Radiology and Imaging
Monosaccharides
Squamous Cell Carcinomas
Hematology
Middle Aged
Magnetic Resonance Imaging
Head and Neck Tumors
Body Fluids
Perfusion
Chemistry
medicine.anatomical_structure
Blood
Oncology
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Physical Sciences
Carcinoma, Squamous Cell
Carbohydrate Metabolism
Female
Anatomy
Research Article
Adult
medicine.medical_specialty
Imaging Techniques
Carbohydrates
Carbohydrate metabolism
Biology
Research and Analysis Methods
Carcinomas
03 medical and health sciences
Head and Neck Squamous Cell Carcinoma
Fluorodeoxyglucose F18
Diagnostic Medicine
medicine
Humans
Tumor growth
Aged
Cell Proliferation
Retrospective Studies
business.industry
Squamous Cell Carcinoma of Head and Neck
Pharynx
lcsh:R
Organic Chemistry
Chemical Compounds
Cancers and Neoplasms
Biology and Life Sciences
Magnetic resonance imaging
Blood flow
medicine.disease
Head and neck squamous-cell carcinoma
stomatognathic diseases
Glucose
Metabolism
Positron-Emission Tomography
lcsh:Q
Spin Labels
Radiopharmaceuticals
Nuclear medicine
business
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 11
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....21ef2575613b66357c2572a7222b1e6d