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The GOLIATH Project: Towards an Internationally Harmonised Approach for Testing Metabolism Disrupting Compounds
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, MDPI, 2020, 21 (10), pp.3480. ⟨10.3390/ijms21103480⟩, International journal of molecular sciences, vol 21, iss 10, International Journal of Molecular Sciences, 2020, 21 (10), pp.3480. ⟨10.3390/ijms21103480⟩, International Journal of Molecular Sciences, 21(10). MDPI AG, inrae. 2020, pp.1-18/3480, International Journal of Molecular Sciences, Vol 21, Iss 3480, p 3480 (2020)
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- International audience; The purpose of this project report is to introduce the European "GOLIATH" project, a new research project which addresses one of the most urgent regulatory needs in the testing of endocrine-disrupting chemicals (EDCs), namely the lack of methods for testing EDCs that disrupt metabolism and metabolic functions. These chemicals collectively referred to as "metabolism Int. Int. J. Mol. Sci. 2020, 21, 3480 2 of 18 disrupting compounds" (MDCs) are natural and anthropogenic chemicals that can promote metabolic changes that can ultimately result in obesity, diabetes, and/or fatty liver in humans. This project report introduces the main approaches of the project and provides a focused review of the evidence of metabolic disruption for selected EDCs. GOLIATH will generate the world's first integrated approach to testing and assessment (IATA) specifically tailored to MDCs. GOLIATH will focus on the main cellular targets of metabolic disruption-hepatocytes, pancreatic endocrine cells, myocytes and adipocytes-and using an adverse outcome pathway (AOP) framework will provide key information on MDC-related mode of action by incorporating multi-omic analyses and translating results from in silico, in vitro, and in vivo models and assays to adverse metabolic health outcomes in humans at real-life exposures. Given the importance of international acceptance of the developed test methods for regulatory use, GOLIATH will link with ongoing initiatives of the Organisation for Economic Development (OECD) for test method (pre-)validation, IATA, and AOP development.
- Subjects :
- 0301 basic medicine
obesity
[SDV]Life Sciences [q-bio]
risk assessment
010501 environmental sciences
Endocrine Disruptors
MESH: Risk Assessment
01 natural sciences
lcsh:Chemistry
Adverse Outcome Pathway
Adipocytes
chemicals
MESH: Obesity
lcsh:QH301-705.5
MESH: Fatty Liver
Spectroscopy
diabetes
Biochemistry and Molecular Biology
General Medicine
Integrated approach
Farmakologi och toxikologi
3. Good health
Computer Science Applications
MESH: Endocrine Disruptors
[SDV] Life Sciences [q-bio]
[SDV.TOX] Life Sciences [q-bio]/Toxicology
Risk analysis (engineering)
[SDV.TOX]Life Sciences [q-bio]/Toxicology
Metabolic Networks and Pathways
Project Report
MESH: Diabetes Mellitus
endocrine
0699 Other Biological Sciences
Pharmacology and Toxicology
Catalysis
Inorganic Chemistry
03 medical and health sciences
0399 Other Chemical Sciences
Diabetes Mellitus
Genetics
Humans
Physical and Theoretical Chemistry
Molecular Biology
MESH: Adipocytes
Metabolic and endocrine
0105 earth and related environmental sciences
Metabolic health
Nutrition
0604 Genetics
Chemical Physics
Organic Chemistry
Estrogen
Fatty Liver
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
13. Climate action
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Business
Other Biological Sciences
Other Chemical Sciences
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Biokemi och molekylärbiologi
Subjects
Details
- Language :
- English
- ISSN :
- 16616596 and 14220067
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, MDPI, 2020, 21 (10), pp.3480. ⟨10.3390/ijms21103480⟩, International journal of molecular sciences, vol 21, iss 10, International Journal of Molecular Sciences, 2020, 21 (10), pp.3480. ⟨10.3390/ijms21103480⟩, International Journal of Molecular Sciences, 21(10). MDPI AG, inrae. 2020, pp.1-18/3480, International Journal of Molecular Sciences, Vol 21, Iss 3480, p 3480 (2020)
- Accession number :
- edsair.doi.dedup.....2202958474b27b3598a0b3b52ecf4940