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Could KL-6 levels in COVID-19 help to predict lung disease ?
- Source :
- Respiratory Research
- Publication Year :
- 2021
- Publisher :
- European Respiratory Society, 2021.
-
Abstract
- Background Coronavirus disease COVID-19 has become a public health emergency of international concern. Together with the quest for an effective treatment, the question of the post-infectious evolution of affected patients in healing process remains uncertain. Krebs von den Lungen 6 (KL-6) is a high molecular weight mucin-like glycoprotein produced by type II pneumocytes and bronchial epithelial cells. Its production is raised during epithelial lesions and cellular regeneration. In COVID-19 infection, KL-6 serum levels could therefore be of interest for diagnosis, prognosis and therapeutic response evaluation. Materials and methods Our study retrospectively compared KL-6 levels between a cohort of 83 COVID-19 infected patients and two other groups: healthy subjects (n = 70) on one hand, and a heterogenous group of patients suffering from interstitial lung diseases (n = 31; composed of 16 IPF, 4 sarcoidosis, 11 others) on the other hand. Demographical, clinical and laboratory indexes were collected. Our study aims to compare KL-6 levels between a COVID-19 population and healthy subjects or patients suffering from interstitial lung diseases (ILDs). Ultimately, we ought to determine whether KL-6 could be a marker of disease severity and bad prognosis. Results Our results showed that serum KL-6 levels in COVID-19 patients were increased compared to healthy subjects, but to a lesser extent than in patients suffering from ILD. Increased levels of KL-6 in COVID-19 patients were associated with a more severe lung disease. Discussion and conclusion Our results suggest that KL-6 could be a good biomarker to assess ILD severity in COVID-19 infection. Concerning the therapeutic response prediction, more studies are necessary.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Population
Interstitial lung disease
Disease
medicine.disease_cause
Severity of Illness Index
03 medical and health sciences
0302 clinical medicine
Internal medicine
Severity of illness
medicine
Humans
education
Letter to the Editor
Aged
Retrospective Studies
Coronavirus
Aged, 80 and over
education.field_of_study
Lung
business.industry
Public health
KL-6
Mucin-1
Case-control study
COVID-19
Retrospective cohort study
Biomarker
Middle Aged
Prognosis
medicine.disease
030104 developmental biology
medicine.anatomical_structure
030228 respiratory system
Case-Control Studies
Cohort
Biomarker (medicine)
Female
Lung infection
Sarcoidosis
Lung Diseases, Interstitial
business
Biomarkers
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Respiratory infections and bronchiectasis
- Accession number :
- edsair.doi.dedup.....2207830dbb67fc16c656c6dbbde6b6da