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Ferric carboxymaltose for iron deficiency at discharge after acute heart failure

Authors :
Stefano Savonitto
D Soon
V Tseluyko
J Heymeriks
L Petrescu
Fabio T. M. Costa
P Garcia Pacho
G Chapidze
Michael Motro
M Diez
A Prado
Piotr Ponikowski
Sanjib Kumar Sharma
DL Serban
A. Salvioni
S del Prado
Giuseppe Boriani
Stephan von Haehling
HG Cestari
PR Nierop
LC Iosipescu
Hans Kragten
Má Hominal
Bridget-Anne Kirwan
Andre Keren
D Horvat
J Thierer
D Sim
Rabih R. Azar
Peter van der Meer
G Stanciulescu
F Cosmi
Sy Loh
Jarosław Drożdż
David Sim
K Paposhvili
M Berli
Alain Cohen-Solal
Stefan D. Anker
Arnaout
ML Parody
GO Zapata
T Ben-Gal
J Schaap
Bas L.J.H. Kietselaer
O Raed
G Kiwan
Marco Metra
Shaul Atar
Udo Michael Göhring
Edoardo Gronda
A Ružić
C Beltrano
Dpw Beelen
Davor Milicic
R Ray
JM Weinstein
FI Ga Bosa Ojeda
Y-K Wong
Dalton Bertolim Précoma
Javed Butler
JR Gonzalez Juanatey
V Chumburidze
Gerasimos Filippatos
V Witzling
Y Malynovsky
I Kraiz
A Samodol
J Trevelyan
L Nigro Maia
M Stanislavchuk
Gilmar Reis
I Khintibidze
D Zdrenghea
Beata Wożakowska-Kapłon
BD Molina
C Abdallah
Ham van Kesteren
Tim Friede
Marcin Gruchała
Majdi Halabi
Ewa A. Jankowska
P Van Bergen
Constantin Militaru
O Koval
DA Darabantiu
A Kormann
J Szachniewicz
Maria Dorobantu
M van de Wetering
R Nijmeijer
H Hamdan
Stefano Ghio
Henry J. Dargie
G Azize
Nicolas Danchin
S Chaaban
S Gerward
P Pimentel Filho
M Uguccioni
K Abdelbaki
N Vita
J.F.K. Saraiva
D Almeida
Michael Shochat
M Ohlsson
R Van de Wal
V Zolotaikina
W Kinany
A Tycińska
A Hershson
T Shaburishvili
Vincent Fabien
FR dos Santos
Alfredo Bardají
Rgej Groutars
M Flugelman
J Bono
M Udovicic
M Artuković
K Šutalo
J Drozdz
TJ Yeo
F Ferre Pacora
Z Lominadze
M Emans
S Pettit
HA Luquez
P Terrosu
Marcus Ohlsson
M Gąsior
S Tušek
Enrico Passamonti
Nyy Al-Windy
P Midi
DA Pascual Figal
P van der Meer
V Zvi
Wilco Tanis
Felipe Martinez
RR Borelli
Diana A. Gorog
O Parhomenko
Klaus H Jensen
M Meijs
J Nessler
M Piepoli
DM Toader
Jose C. Nicolau
A Glenny
José Luis Zamorano
L Tilling
T McDonagh
K Pesek
H Fernandez
Davor Miličić
Domingo A. Pascual-Figal
Theresa McDonagh
G Khabeishvili
Josep Comin-Colet
Israel Gotsman
S Rassi
M Dorobantu
E Straburzyńska-Migaj
L Fattore
L Rudenko
D Crisu
S.S. Kabbani
M Gomez Bueno
Basil S. Lewis
S Goland
Y Arbel
M Bronisz
I Vakaliuk
A Fucili
A Mortara
R Zukermann
N Emukhvari
B Hassouna
K Mizia-Stec
F Turrini
R Szelemej
A Rodica Dan
L Lobo Marquez
Hadi Skouri
A Kabir
Frank Ruschitzka
R García Durán
R Gil
Michael Shechter
P Westendorp
Piergiuseppe Agostoni
A Fernandez
Oscar Pereira Dutra
P Ameri
Wolfram Doehner
JG Smith
Irakli Khintibidze
Luciano Moreira Baracioli
J Šikić
Stuart Pocock
Olivier C. Manintveld
MC Tomescu
M Di Biase
Luiz Carlos Bodanese
E Mirek-Bryniarska
Alexander Parkhomenko
Cardiovascular Centre (CVC)
Restoring Organ Function by Means of Regenerative Medicine (REGENERATE)
Cardiology
leboeuf, Christophe
Wrocław Medical University
London School of Hygiene and Tropical Medicine (LSHTM)
Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
King's College Hospital (KCH)
Universitatea din Bucuresti (UB)
University of Lódź
Vifor Pharma Ltd [Glattbrugg, Switzerland]
National and Kapodistrian University of Athens (NKUA)
Hadassah Hebrew University Medical Center [Jerusalem]
Tbilisi State University
Maastricht University Medical Centre (MUMC)
Maastricht University [Maastricht]
Prague University of Economics and Business
Università degli Studi di Brescia = University of Brescia (UniBs)
University of Zagreb
Universidade de São Paulo = University of São Paulo (USP)
Skane University Hospital [Malmo]
Lund University [Lund]
National Scientific Center 'M.D. Strazhesko Institute of Cardiology' [Kyiv, Ukraine] (NSC/MDSIC)
Universidad de Murcia
University hospital of Zurich [Zurich]
National Heart Centre Singapore (NHCS)
Saint Joseph Medical Center [Beirut]
University Medical Center Groningen [Groningen] (UMCG)
Clinical Cardiovascular Research Institute [Haifa, Israel] (2CRI)
Bellvitge University Hospital [Barcelona, Spain]
University Medical Center Göttingen (UMG)
Biomarqueurs CArdioNeuroVASCulaires (BioCANVAS)
Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Hôpital Européen Georges Pompidou [APHP] (HEGP)
Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)
Charité Campus Virchow-Klinikum (CVK)
University of Glasgow
Tel Aviv University (TAU)
University of Southern Mississippi (USM)
Socar Research S.A. [Nyon, Switzerland] (SR)
AFFIRM-AHF investigators: G Azize, A Fernandez, G O Zapata, P Garcia Pacho, A Glenny, F Ferre Pacora, M L Parody, J Bono, C Beltrano, A Hershson, N Vita, H A Luquez, H G Cestari, H Fernandez, A Prado, M Berli, R García Durán, J Thierer, M Diez, L Lobo Marquez, R R Borelli, M Á Hominal, M Metra, P Ameri, P Agostoni, A Salvioni, L Fattore, E Gronda, S Ghio, F Turrini, M Uguccioni, M Di Biase, M Piepoli, S Savonitto, A Mortara, P Terrosu, A Fucili, G Boriani, P Midi, E Passamonti, F Cosmi, P van der Meer, P Van Bergen, M van de Wetering, Nyy Al-Windy, W Tanis, M Meijs, Rgej Groutars, Hks The, B Kietselaer, Ham van Kesteren, Dpw Beelen, J Heymeriks, R Van de Wal, J Schaap, M Emans, P Westendorp, P R Nierop, R Nijmeijer, O C Manintveld, M Dorobantu, D A Darabantiu, D Zdrenghea, D M Toader, L Petrescu, C Militaru, D Crisu, M C Tomescu, G Stanciulescu, A Rodica Dan, L C Iosipescu, D L Serban, J Drozdz, J Szachniewicz, M Bronisz, A Tycińska, B Wozakowska-Kaplon, E Mirek-Bryniarska, M Gruchała, J Nessler, E Straburzyńska-Migaj, K Mizia-Stec, R Szelemej, R Gil, M Gąsior, I Gotsman, M Halabi, M Shochat, M Shechter, V Witzling, R Zukermann, Y Arbel, M Flugelman, T Ben-Gal, V Zvi, W Kinany, J M Weinstein, S Atar, S Goland, D Milicic, D Horvat, S Tušek, M Udovicic, K Šutalo, A Samodol, K Pesek, M Artuković, A Ružić, J Šikić, T McDonagh, J Trevelyan, Y-K Wong, D Gorog, R Ray, S Pettit, S Sharma, A Kabir, H Hamdan, L Tilling, L Baracioli, L Nigro Maia, O Dutra, G Reis, P Pimentel Filho, J F Saraiva, A Kormann, F R Dos Santos, L Bodanese, D Almeida, D Precoma, S Rassi, F Costa, S Kabbani, K Abdelbaki, C Abdallah, M S Arnaout, R Azar, S Chaaban, O Raed, G Kiwan, B Hassouna, A Bardaji, J Zamorano, S Del Prado, J R Gonzalez Juanatey, F I Ga Bosa Ojeda, M Gomez Bueno, B D Molina, D A Pascual Figal, D Sim, T J Yeo, S Y Loh, D Soon, M Ohlsson, J G Smith, S Gerward, I Khintibidze, Z Lominadze, G Chapidze, N Emukhvari, G Khabeishvili, V Chumburidze, K Paposhvili, T Shaburishvili, G Khabeishvili, O Parhomenko, I Kraiz, O Koval, V Zolotaikina, Y Malynovsky, I Vakaliuk, L Rudenko, V Tseluyko, M Stanislavchuk.
Source :
LANCET, 396(10266), 1895-1904. ELSEVIER SCIENCE INC, The Lancet, The Lancet, 396(10266), 1895-1904. Elsevier Ltd., The Lancet, 2020, 396 (10266), pp.1895-1904. ⟨10.1016/S0140-6736(20)32339-4⟩
Publication Year :
2020
Publisher :
Elsevier Ltd., 2020.

Abstract

Background: Intravenous ferric carboxymaltose has been shown to improve symptoms and quality of life in patients with chronic heart failure and iron deficiency. We aimed to evaluate the effect of ferric carboxymaltose, compared with placebo, on outcomes in patients who were stabilised after an episode of acute heart failure. Methods: AFFIRM-AHF was a multicentre, double-blind, randomised trial done at 121 sites in Europe, South America, and Singapore. Eligible patients were aged 18 years or older, were hospitalised for acute heart failure with concomitant iron deficiency (defined as ferritin

Subjects

Subjects :
Male
medicine.medical_specialty
Anemia
030204 cardiovascular system & hematology
Rate ratio
Placebo
Ferric Compounds
Ventricular Function, Left
law.invention
03 medical and health sciences
0302 clinical medicine
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Double-Blind Method
Randomized controlled trial
law
Internal medicine
medicine
Humans
030212 general & internal medicine
Maltose
Adverse effect
TOLVAPTAN
Aged
Aged, 80 and over
Heart Failure
RISK
Ejection fraction
Anemia, Iron-Deficiency
business.industry
MORTALITY
Hazard ratio
DEATH
General Medicine
Middle Aged
medicine.disease
Patient Discharge
[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
3. Good health
Hospitalization
Treatment Outcome
Heart failure
Administration, Intravenous
Female
HOSPITALIZATIONS
business

Details

Language :
English
ISSN :
1474547X and 01406736
Volume :
396
Issue :
10266
Database :
OpenAIRE
Journal :
The Lancet
Accession number :
edsair.doi.dedup.....221bf735e50009e83726ce7dc2a55d76
Full Text :
https://doi.org/10.1016/S0140-6736(20)32339-4⟩
Full Text Access
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