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Nasal Bone Shape Is under Complex Epistatic Genetic Control in Mouse Interspecific Recombinant Congenic Strains
- Source :
- PLoS ONE, Vol 7, Iss 5, p e37721 (2012), PLoS ONE, PLoS ONE, Public Library of Science, 2012, 7 (5), pp.e37721. ⟨10.1371/journal.pone.0037721⟩, PLoS ONE, 2012, 7 (5), pp.e37721. ⟨10.1371/journal.pone.0037721⟩
- Publication Year :
- 2012
- Publisher :
- Public Library of Science (PLoS), 2012.
-
Abstract
- International audience; Background: Genetic determinism of cranial morphology in the mouse is still largely unknown, despite the localization of putative QTLs and the identification of genes associated with Mendelian skull malformations. To approach the dissection of this multigenic control, we have used a set of interspecific recombinant congenic strains (IRCS) produced between C57BL/6 and mice of the distant species Mus spretus (SEG/Pas). Each strain has inherited 1.3% of its genome from SEG/Pas under the form of few, small-sized, chromosomal segments.Results: The shape of the nasal bone was studied using outline analysis combined with Fourier descriptors, and differential features were identified between IRCS BcG-66H and C57BL/6. An F2 cross between BcG-66H and C57BL/6 revealed that, outof the three SEG/Pas-derived chromosomal regions present in BcG-66H, two were involved. Segments on chromosomes 1~32 Mb) and 18 (~13 Mb) showed additive effect on nasal bone shape. The three chromosomal regions present in BcG-66H were isolated in congenic strains to study their individual effect. Epistatic interactions were assessed in bicongenicstrains.Conclusions: Our results show that, besides a strong individual effect, the QTL on chromosome 1 interacts with genes onchromosomes 13 and 18. This study demonstrates that nasal bone shape is under complex genetic control but can beefficiently dissected in the mouse using appropriate genetic tools and shape descriptors.
- Subjects :
- Male
0106 biological sciences
Anatomy and Physiology
Heredity
Mouse
MESH: Nasal Bone
Gene Identification and Analysis
lcsh:Medicine
01 natural sciences
Genome
Loss of heterozygosity
Mice
Molecular Cell Biology
MESH: Epistasis, Genetic
Nasal Bone
MESH: Animals
lcsh:Science
Musculoskeletal System
Genetics
0303 health sciences
Multidisciplinary
Chromosome Biology
Strain (biology)
Chromosome Mapping
Genomics
Animal Models
MESH: Crosses, Genetic
Fourier analysis
Medicine
Female
Research Article
Quantitative trait loci
Linear discriminant analysis
DNA recombination
Mus spretus
Congenic
Biology
Quantitative trait locus
010603 evolutionary biology
Molecular Genetics
Mice, Congenic
03 medical and health sciences
Model Organisms
MESH: Mice, Congenic
MESH: Mice, Inbred C57BL
Animals
Inbred strains
Mammalian genomics
Bone
MESH: Mice
Crosses, Genetic
Alleles
030304 developmental biology
[SDV.GEN]Life Sciences [q-bio]/Genetics
Quantitative Traits
Skull
lcsh:R
Computational Biology
Chromosome
Epistasis, Genetic
biology.organism_classification
MESH: Quantitative Trait Loci
MESH: Male
Mice, Inbred C57BL
Epistasis
lcsh:Q
Gene Function
MESH: Chromosome Mapping
Animal Genetics
MESH: Female
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....2244e8ae0c4b90305cdc3ae697218e62