Back to Search
Start Over
Excess free fructose, apple juice, high fructose corn syrup and childhood asthma risk – the National Children’s Study
- Source :
- Nutrition Journal, Vol 19, Iss 1, Pp 1-13 (2020), Nutrition Journal
- Publication Year :
- 2020
- Publisher :
- BMC, 2020.
-
Abstract
- BackgroundRecent research provides consistent evidence that the unexplained doubling of childhood asthma prevalence (1980–1995), its continued climb and 2013 plateau, may be associated with the proliferation of high-fructose-corn-syrup (HFCS) in the US food supply. The HFCS used in soft drinks has been shown to contain a higher fructose-to-glucose ratio than previously thought. This coincides with a preference shift from orange to apple juice among young children. Apple juice naturally contains a high (≥2:1) fructose-to-glucose ratio. Thus, children have received high excess-free-fructose doses, the fructose type associated with fructose malabsorption. Unabsorbed excess-free-fructose in the gut may react with dietary proteins to form immunogens that bind asthma mediating receptors, and/or alter the microbiota towards a profile linked to lung disorders. Studies with longitudinal childhood data are lacking. Therefore, we tested the hypothesis that excess-free-fructose intake is associated with childhood asthma risk.MethodsCox regression models were used to analyze prospective early childhood data (12–30 months of age) from the National Children’s Study. Intake frequencies for soda/sports/fruit drinks, and 100% juices were used for analyses.ResultsGreater consumption of 100% juice, soda/sports/fruit drinks, and any combination, was associated with ~two (P = 0.001), ~ 2.5 (P = 0.001), and ~ 3.5 times (P ConclusionsGiven these results, prior research and case-study evidence, it is reasonable to suggest that the two-fold higher asthma risk associated with 100% juice consumption is due to apple juice’s high fructose-to-glucose ratio, and that the ~ 2.5/~ 3.5 times higher risk associated with soda/sports/fruit drinks intake is with the excess-free-fructose in HFCS.
- Subjects :
- Apple juice
Medicine (miscellaneous)
Fructose malabsorption
FODMAP
lcsh:TX341-641
Clinical nutrition
Fructose
Beverages
chemistry.chemical_compound
AGE
National Children's Study
Medicine
Humans
High fructose corn syrup
Food science
Prospective Studies
Fruit drinks
Advanced glycation end-products
Fructositis
Child
lcsh:RC620-627
Asthma
chemistry.chemical_classification
Excess free fructose
Juice
Nutrition and Dietetics
business.industry
High-fructose corn syrup
Proportional hazards model
Research
medicine.disease
Soft drinks
RAGE
lcsh:Nutritional diseases. Deficiency diseases
chemistry
Child, Preschool
Malus
FruAGE
Microbiome
Soda
business
lcsh:Nutrition. Foods and food supply
Subjects
Details
- Language :
- English
- ISSN :
- 14752891
- Volume :
- 19
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nutrition Journal
- Accession number :
- edsair.doi.dedup.....22488452d6b9149c93700e1f3aaf7eb6