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Does an imbalance in circulating vascular endothelial growth factors (VEGFs) cause atrial fibrillation in patients with valvular heart disease?
- Source :
- Journal of thoracic disease. 11(12)
- Publication Year :
- 2020
-
Abstract
- BACKGROUND: The pathogenesis of atrial fibrillation (AF) remains unclear. Vascular endothelial growth factors (VEGFs) can stimulate fibrosis within the atrium and ventricle. We hypothesized that there is a relationship between the serum VEGFs/soluble vascular endothelial growth factor receptor (sVEGFRs) levels and AF in patients with valvular heart disease (VHD). This provides a new paradigm for studying AF. METHODS: The plasma levels of VEGF-A, VEGF-C, sVEGFR-1 and sVEGFR-2 were detected by enzyme-linked immunosorbent assay (ELISA). A total of 100 people, consisting of AF patients (long-standing, persistent AF; n=49), sinus rhythm (SR) patients (n=31) and healthy controls (n=20), were included in this study. RESULTS: The plasma levels of VEGF-A were significantly higher in AF patients compared to healthy control (P
- Subjects :
- 0301 basic medicine
Pulmonary and Respiratory Medicine
medicine.medical_specialty
business.industry
Angiogenesis
valvular heart disease
Atrial fibrillation
030204 cardiovascular system & hematology
medicine.disease
Lymphangiogenesis
Pathogenesis
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
medicine.anatomical_structure
Ventricle
Fibrosis
Internal medicine
medicine
Cardiology
Sinus rhythm
Original Article
business
Subjects
Details
- ISSN :
- 20721439
- Volume :
- 11
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of thoracic disease
- Accession number :
- edsair.doi.dedup.....22918de01686a1fc715a6e043c87b1d4