Back to Search
Start Over
GPX4 and GPX7 over-expression in human hepatocellular carcinoma tissues
- Source :
- European Journal of Histochemistry, Vol 59, Iss 4 (2015), European Journal of Histochemistry : EJH
- Publication Year :
- 2015
-
Abstract
- Hepatocellular carcinoma (HCC) is the most common type of liver cancer and is still one of the most fatal cancers. Hence, it needs to identify always new putative markers to improve its diagnosis and prognosis. The selenium is an essential trace mineral implicated as a key factor in the early stage of cancer and exerts its biological function through the selenoproteins. In the last years our group has been studying the involvement of some selenoproteins in HCC. However, no many data are reported in literature about the correlation between HCC and the glutathione peroxidases (GPXs), both selenium and non selenium-containing GPXs. In this paper we have evaluated the GPX4 and GPX7 expression in some paraffin-embedded tissues from liver biopsy of patients with hepatitis C virus (HCV)-related cirrhosis and HCC by immunohistochemistry and RT-qPCR analysis. Our results evidenced that i) GPX4 and GPX7 had a statistically significant over-expression in HCC tissues compared to cirrhotic counterparts used as non tumor tissues, and ii) their expression was higher in grade III HCC tissues with respect to grade I-II samples. Therefore, we propose to use GPX4 and GPX7 as possible markers for improving HCC diagnosis/prognosis.
- Subjects :
- Male
Pathology
Cirrhosis
Hepatocellular carcinoma
medicine.disease_cause
0302 clinical medicine
lcsh:QH301-705.5
Aged, 80 and over
0303 health sciences
medicine.diagnostic_test
Brief Report
Liver Neoplasms
Middle Aged
Immunohistochemistry
Neoplasm Proteins
3. Good health
Gene Expression Regulation, Neoplastic
Peroxidases
030220 oncology & carcinogenesis
Liver biopsy
Female
Liver cancer
medicine.medical_specialty
Carcinoma, Hepatocellular
Histology
Hepatitis C virus
Biophysics
Biology
Gene Expression Regulation, Enzymologic
03 medical and health sciences
Biomarkers, Tumor
medicine
Carcinoma
Humans
Aged
030304 developmental biology
Glutathione Peroxidase
GPX7
RT-qPCR
Cancer
Cell Biology
Phospholipid Hydroperoxide Glutathione Peroxidase
medicine.disease
digestive system diseases
lcsh:Biology (General)
Cancer research
GPX4
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- European Journal of Histochemistry, Vol 59, Iss 4 (2015), European Journal of Histochemistry : EJH
- Accession number :
- edsair.doi.dedup.....2298594cefb179fe9ae67ae4f500d0f0